Cited 11 times in

How to improve treatment outcomes for hepatocellular carcinoma of intermediate and advanced stage.

Title
 How to improve treatment outcomes for hepatocellular carcinoma of intermediate and advanced stage. 
Authors
 Kim D.Y. ; Han K.-H. 
Issue Date
2012
Journal Title
 Digestive Diseases 
ISSN
 0257-2753 
Citation
 Digestive Diseases, Vol.30(6) : 598~602, 2012 
Abstract
Hepatocellular carcinoma (HCC) consists of heterogeneous tumors regarding morphology, biology, and underlying liver function. In intermediate stage HCC, a high rate of recurrence and unsatisfactory treatment outcome after transarterial chemoembolization (TACE) are usually due to a large size and high number of tumors. TACE using drug-eluting beads has an advantage of a higher concentration of chemotherapeutic agent in the tumor. It might be applied to the patients with advanced diseases such as bilobar or recurrent HCC, and poor liver function. Blocking angiogenic stimuli after TACE would be a rational approach and radioembolization with (90)Y is a novel interventional modality for intermediate stage HCC. The modest anti-cancer effect of sorafenib coupled with an adverse event is a hurdle to overcome in advanced HCC. External radiotherapy has achieved promising results in HCC with portal vein invasion. The role of internal radiation therapy with (90)Y is not yet clear in advanced HCC. The safety and efficacy of hepatic arterial infusion chemotherapy have been reported in several studies. However, as in external radiotherapy, a well-designed randomized result is lacking. An appropriate combination strategy based on baseline patient and tumor characteristics may increase the survival of patients with intermediate or advanced HCC.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/90140
DOI
10.1159/000343088
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
사서에게 알리기
  feedback
Link
 http://www.karger.com/Article/FullText/343088
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse