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Post-transplant lymphoproliferative disorders: clinicopathological analysis of 43 cases in a single center, 1990-2009.

Authors
 Sun Och Yoon ; Eunsil Yu ; Jooryung Huh ; Seung Gyu Lee ; Duck Jong Han ; Kyung Mo Kim ; Cheolwon Suh ; Yong Mee Cho 
Citation
 Clinical Transplantation, Vol.26(1) : 67~73, 2012 
Journal Title
 Clinical Transplantation 
ISSN
 0902-0063 
Issue Date
2012
Abstract
Post-transplant lymphoproliferative disorders (PTLDs) are a heterogeneous set of complications of organ transplantation associated with poor patient prognosis. We analyzed the clinicopathological features of PTLDs in 43 adult and pediatric recipients of solid organ or bone marrow transplantation at a large transplant service in the Republic of Korea between 1990 and 2009. Of 4545 solid organ and 747 bone marrow transplant recipients, 37 (0.81%) and 6 (0.8%), respectively, developed heterogeneous types of PTLDs. The cumulative incidences of PTLDs during this period were 1.79% (4/223) for heart transplant recipients, 0.78% (17/2192) for kidney transplant recipients, and 0.77% (16/2067) for liver transplant recipients. The patterns of disease onset, histology, and patient survival were associated with the types of organs transplanted. There is a trend for shorter overall survival (OS) in recipients with early-onset PTLDs and monomorphic PTLD histology, while kidney transplant recipients showed favorable OS. This study may be the first comprehensive analysis of the characteristics of PTLDs in Korean patients.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/90051
DOI
10.1111/j.1399-0012.2010.01392.x
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1111/j.1399-0012.2010.01392.x/abstract
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