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The association of specific metabolites of lipid metabolism with markers of oxidative stress, inflammation and arterial stiffness in men with newly diagnosed type 2 diabetes.

Authors
 Chang Young Ha  ;  Ji Young Kim  ;  Jean Kyung Paik  ;  Oh Yoen Kim  ;  Yong-Han Paik  ;  Eun Jig Lee  ;  Jong Ho Lee 
Citation
 CLINICAL ENDOCRINOLOGY, Vol.76(5) : 674-682, 2012 
Journal Title
CLINICAL ENDOCRINOLOGY
ISSN
 0300-0664 
Issue Date
2012
MeSH
Adult ; Aged ; Biomarkers/blood ; Blood Glucose/metabolism ; C-Reactive Protein/metabolism ; Chromatography, High Pressure Liquid/methods ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/metabolism* ; Humans ; Inflammation/blood ; Inflammation/metabolism* ; Interleukin-6/blood ; Lipid Metabolism* ; Lipid Peroxides/blood ; Lipids/blood ; Lipids/chemistry ; Lipoproteins, LDL/blood ; Male ; Mass Spectrometry/methods ; Metabolome ; Metabolomics/methods ; Middle Aged ; Multivariate Analysis ; Oxidative Stress* ; Phospholipids/blood ; Triglycerides/blood ; Tumor Necrosis Factor-alpha/blood ; Vascular Stiffness*
Keywords
Adult ; Aged ; Biomarkers/blood ; Blood Glucose/metabolism ; C-Reactive Protein/metabolism ; Chromatography, High Pressure Liquid/methods ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/metabolism* ; Humans ; Inflammation/blood ; Inflammation/metabolism* ; Interleukin-6/blood ; Lipid Metabolism* ; Lipid Peroxides/blood ; Lipids/blood ; Lipids/chemistry ; Lipoproteins, LDL/blood ; Male ; Mass Spectrometry/methods ; Metabolome ; Metabolomics/methods ; Middle Aged ; Multivariate Analysis ; Oxidative Stress* ; Phospholipids/blood ; Triglycerides/blood ; Tumor Necrosis Factor-alpha/blood ; Vascular Stiffness*
Abstract
OBJECTIVE: To determine whether circulating metabolic intermediates are associated with inflammation, oxidative stress and arterial stiffness in men with newly diagnosed type 2 diabetes and investigate the circulating metabolic intermediates that may predict the risk of developing diabetes.

RESEARCH DESIGN AND METHODS: Men with newly diagnosed type 2 diabetes (n = 26) and age- and body mass index-matched nondiabetic men (n = 27) were included. We measured inflammatory and oxidative markers and arterial stiffness by brachial-ankle pulse wave velocity (ba-PWV). Metabolomic profiling was analysed with ultra performance liquid chromatography and quadrupole time-of-flight mass spectrometry.

RESULTS: Diabetic men showed higher circulating levels of glucose, triglyceride, oxidized low-density lipoprotein (LDL), high-sensitivity C-reactive protein, interleukin (IL)-6, tumour necrosis factor-alpha (TNF-α), homeostasis model assessment-insulin resistance, urinary 8-epi-prostaglandin F(2α) (8-epi-PGF(2α)) and ba-PWV than nondiabetic men. In plasma, 19 metabolites including three amino acids, eight acylcarnitines, six lysophosphatidylcholines (lysoPCs), and two lysophosphatidylethanolamines (lysoPEs; C18:2 and C22:6) significantly increased in diabetes men, whereas serine and lysoPE (C18:1) decreased. Decanoyl carnitine, lysoPCs (C14:0, C16:1, C18:1 and C22:6) and lysoPE (C18:1) with variable importance in the projection values >1·0 were major plasma metabolites that distinguished nondiabetic and diabetic men. Decanoyl carnitine positively correlated with oxidized LDL, 8-epi-PGF(2α), IL-6, TNF-α and ba-PWV. ba-PWV correlated positively with lysoPCs C14:0 and C16:1, and negatively with lysoPE C18:1. 8-epi-PGF(2α) correlated positively with lipoprotein-associated phospholipase A(2), ba-PWV and lysoPCs (C14:0 and C16:1). The receiver operating characteristic curve estimation suggested that decanoyl carnitine and lysoPC (C14:0) are the best metabolites for predicting the risk of developing diabetes.

CONCLUSIONS: Circulating lipid-related intermediate metabolites can be closely associated with inflammation, oxidative stress and arterial stiffness in early diabetes.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2011.04244.x/abstract
DOI
21958081
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Eun Jig(이은직) ORCID logo https://orcid.org/0000-0002-9876-8370
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90016
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