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Urinary ketone is associated with the heart failure severity.

Authors
 Ji Hyung Chung ; Jin-Sup Kim ; Min-Jeong Shin ; Geum-Sook Hwang ; Seok-Min Kang ; Oh Yoen Kim 
Citation
 Clinical Biochemistry, Vol.45(18) : 1697~1699, 2012 
Journal Title
 Clinical Biochemistry 
ISSN
 0009-9120 
Issue Date
2012
Abstract
OBJECTIVES: To test the hypothesis that urinary metabolites characterizing heart failure (HF) are associated with the magnitude of echocardiographic measurements and ultimately the severity of HF. DESIGN/METHODS: Patients with systolic HF (n=46) and control subjects (n=32) participated in this study. Patients with type 2 diabetes mellitus were excluded. Echocardiographic measurements were performed, and selected urinary metabolites were quantified. RESULTS: Urinary levels of acetate (p<0.05), acetone (p<0.01), cytosine (p<0.001), methylmalonate (p<0.001), and phenylacetylglycine (p<0.01) were significantly higher, while 1-methylnicotinamide (p<0.05) were significantly lower in HF patients than in controls. There were significant differences in E/E' (p<0.05), urinary levels of acetate (p<0.005), acetoacetate (p<0.05), acetone (p<0.05) and ketones (p<0.01) according to the New York Heart Association (NYHA) classification in HF patients. Multiple linear regression analysis revealed that urinary ketones were found to be independent factors for both left ventricular ejection fraction and E/E' after adjusting for confounders. CONCLUSION: Our results showed that urinary levels of ketone bodies are associated with the magnitude of echocardiographic parameters.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/90008
DOI
10.1016/j.clinbiochem.2012.08.013
Appears in Collections:
1. 연구논문 > 5. Research Institutes > Cardiovascular Product Evaluation Center
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0009912012004936
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