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Association between serum total bilirubin level and leukoaraiosis in Korean adults.

Authors
 Byoung-Jin Parka ; Jae-Yong Shima ; Yong-Jae Leea ; Jung-Hyun Leeb ; Hee-Taik Kanga ; Hye-Ree Leea 
Citation
 Clinical Biochemistry, Vol.45(4-5) : 289~292, 2012 
Journal Title
 Clinical Biochemistry 
ISSN
 0009-9120 
Issue Date
2012
Abstract
OBJECTIVES: Leukoaraiosis is associated with cerebrovascular microangiopathy. Increasing evidence suggests that bilirubin is a potent cytoprotectant in the development of cardiovascular diseases. This study aimed to determine whether total bilirubin is related to leukoaraiosis. METHODS: We examined the relationship of total bilirubin with leukoaraiosis in 1005 Korean adults. The odds ratios for leukoaraiosis were calculated using multivariate logistic regression across serum total bilirubin tertiles. RESULTS: In comparison with the subjects in the reference group (total bilirubin: 15-26 μmol/L), the odds ratio (95% CI) for leukoaraiosis in the 3rd tertile (total bilirubin ≤10 μmol/L) was 5.50 (1.24-24.40) in women after adjusting for confounding variables. However, this inverse association between serum total bilirubin and the prevalence of leukoaraiosis was not found in men after adjusting for the same co-variables. CONCLUSION: Total bilirubin level was inversely associated with leukoaraiosis regardless of classical cardiovascular risk factors in Korean women.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/90005
DOI
10.1016/j.clinbiochem.2011.12.023
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Family Medicine
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0009912012000021
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