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Emerging clinical and experimental evidence for the role of lipocalin-2 in metabolic syndrome.

Title
Emerging clinical and experimental evidence for the role of lipocalin-2 in metabolic syndrome.
Authors
Yangsoo Jang;Jong Ho Lee;Gary Sweeney;Yu Wang
Issue Date
2012
Journal Title
Clinical and Experimental Pharmacology and Physiology
ISSN
0305-1870
Citation
Clinical and Experimental Pharmacology and Physiology, Vol.39(2) : 194~199, 2012
Abstract
The inflammatory state, which is associated with the current pandemic of obesity, has been established as an important contributing pathogenic factor to the increased prevalence of the so-called metabolic syndrome. Many studies have focused on the contribution of various adipokines to this phenomenon, and in the present study, we provide an update on the emerging evidence that the pro-inflammatory factor, lipocalin-2, might influence various aspects of metabolic syndrome. Previous reports indicate a positive correlation of serum lipocalin-2 with fasting glucose, the homeostasis model assessment of insulin resistance index, and the inflammatory marker high-sensitivity C-reactive protein, even after adjustment for body mass index, suggesting that it is an independent risk factor for insulin resistance, diabetes, and inflammation. Direct analysis of lipocalin-2 action now also shows effects on peripheral metabolism and on cardiovascular function. A better understanding of how lipocalin-2 is regulated locally and systemically is crucial for adding to our understanding of the pathogenesis of metabolic syndrome, and to uncover potential new avenues for therapeutic approaches.
URI
http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1681.2011.05557.x/abstract

http://ir.ymlib.yonsei.ac.kr/handle/22282913/89997
DOI
10.1111/j.1440-1681.2011.05557.x
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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