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Effect of combined remote ischemic preconditioning and postconditioning on pulmonary function in valvular heart surgery.

Title
 Effect of combined remote ischemic preconditioning and postconditioning on pulmonary function in valvular heart surgery. 
Authors
 Jong-Chan Kim ; Jae-Kwang Shim ; Young-Lan Kwak ; So-Young Yang ; Young-Chul Yoo ; Sak Lee 
Issue Date
2012
Journal Title
 Chest 
ISSN
 0012-3692 
Citation
 Chest, Vol.142(2) : 467~475, 2012 
Abstract
BACKGROUND: The aim of this study was to evaluate the lung-protective effect of combined remote ischemic preconditioning (RIPCpre) and postconditioning (RIPCpost) in patients undergoing complex valvular heart surgery. METHODS: In this randomized, placebo-controlled, double-blind trial, 54 patients were assigned to an RIPCpre plus RIPCpost group or a control group (1:1). Patients in the RIPCpre plus RIPCpost group received three 10-min cycles of right-side lower-limb ischemia of 250 mm Hg at both 10 min after anesthetic induction and weaning from cardiopulmonary bypass. The primary end point was to compare postoperative Pao(2)/Fio(2). Secondary end points were to compare pulmonary variables, incidence of acute lung injury, and inflammatory cytokines. RESULTS: In both groups, Pao(2)/Fio(2) at 24 h postoperation was significantly decreased compared with each corresponding baseline value. However, intergroup comparisons of pulmonary variables, including Pao(2)/Fio(2) and incidence of acute lung injury, revealed no significant differences. Serum levels of IL-6, IL-8, IL-10, and tumor necrosis factor-α were all significantly increased in both groups compared with each corresponding baseline value, without any significant intergroup differences. There were also no significant differences in transpulmonary gradient of IL-6, IL-10, and tumor necrosis factor-α between the groups. CONCLUSIONS: RIPCpre plus RIPCpost as tested in this randomized controlled trial did not provide significant pulmonary benefit following complex valvular cardiac surgery.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/89943
DOI
10.1378/chest.11-2246
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Thoracic & Cardiovascular Surgery
1. 연구논문 > 1. College of Medicine > Dept. of Anesthesiology and Pain Medicine
Yonsei Authors
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Link
 http://journal.publications.chestnet.org/article.aspx?articleid=1262340
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