A facile approach for the delivery of inorganic nanoparticles into the brain by passing through the blood-brain barrier (BBB).
Yeong Shin Yim ; Jin-sil Choi ; Jinwoo Cheon ; Dong Goo Kim ; Tae-Hyun Shin ; Chul Hoon Kim ; Gun Tae Kim
Chemical Communications, Vol.48(1) : 61~63, 2012
This study provides an easy and simple method to obtain inorganic nanoparticles that can penetrate the blood-brain barrier, the heavily guarded system in the brain, via cross-linked serum albumin surface coatings. Their intact BBB permeability was confirmed in both in vitro and in vivo tests.