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Local translation of extranuclear lamin B promotes axon maintenance.

Authors
 Byung C. Yoon ; Hosung Jung ; Christine E. Holt ; Krishna H. Zivraj ; Catherine M. O'Hare ; Asha Dwivedy 
Citation
 Cell, Vol.148(4) : 752~764, 2012 
Journal Title
 Cell 
ISSN
 0092-8674 
Issue Date
2012
Abstract
Local protein synthesis plays a key role in regulating stimulus-induced responses in dendrites and axons. Recent genome-wide studies have revealed that thousands of different transcripts reside in these distal neuronal compartments, but identifying those with functionally significant roles presents a challenge. We performed an unbiased screen to look for stimulus-induced, protein synthesis-dependent changes in the proteome of Xenopus retinal ganglion cell (RGC) axons. The intermediate filament protein lamin B2 (LB2), normally associated with the nuclear membrane, was identified as an unexpected major target. Axonal ribosome immunoprecipitation confirmed translation of lb2 mRNA in vivo. Inhibition of lb2 mRNA translation in axons in vivo does not affect guidance but causes axonal degeneration. Axonal LB2 associates with mitochondria, and LB2-deficient axons exhibit mitochondrial dysfunction and defects in axonal transport. Our results thus suggest that axonally synthesized lamin B plays a crucial role in axon maintenance by promoting mitochondrial function.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/89896
DOI
10.1016/j.cell.2011.11.064
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Anatomy
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0092867412000803
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