Cited 0 times in

AMPKα modulation in cancer progression: multilayer integrative analysis of the whole transcriptome in Asian gastric cancer.

Title
 AMPKα modulation in cancer progression: multilayer integrative analysis of the whole transcriptome in Asian gastric cancer.
Authors
 Yon Hui Kim; Han Liang; Garth Powis; Chang-Gong Liu; John N. Weinstein; Sung Hoon Noh; Hyun Cheol Chung; Ellen M. Beasley; Jingtao Sun; Yongming Sun; Matthew D. Dyer; Thomas J. Downey; Min Li; Hoguen Kim; Jae-Ho Cheong; Jae Yong Cho; Ju-Seog Lee; Xiuping Liu
Issue Date
2012
Journal Title
 Cancer Research
ISSN
 0008-5472
Citation
 Cancer Research, Vol.72(10) : 2512~2521, 2012
Abstract
Gastric cancer is the most common cancer in Asia and most developing countries. Despite the use of multimodality therapeutics, it remains the second leading cause of cancer death in the world. To identify the molecular underpinnings of gastric cancer in the Asian population, we applied an RNA-sequencing approach to gastric tumor and noncancerous specimens, generating 680 million informative short reads to quantitatively characterize the entire transcriptome of gastric cancer (including mRNAs and miRNAs). A multilayer analysis was then developed to identify multiple types of transcriptional aberrations associated with different stages of gastric cancer, including differentially expressed mRNAs, recurrent somatic mutations, and key differentially expressed miRNAs. Through this approach, we identified the central metabolic regulator AMP-activated protein kinase (AMPK)α as a potential functional target in Asian gastric cancer. Furthermore, we experimentally showed the translational relevance of this gene as a potential therapeutic target for early-stage gastric cancer in Asian patients. Together, our findings not only provide a valuable information resource for identifying and elucidating the molecular mechanisms of Asian gastric cancer, but also represent a general integrative framework to develop more effective therapeutic targets.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/89873
DOI
10.1158/0008-5472.CAN-11-3870
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
사서에게 알리기
  feedback
Files in This Item:
T201201069.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse