Cited 0 times in
Risk factors affecting seroconversion after influenza A/H1N1 vaccination in hemodialysis patients.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박형천 | - |
dc.contributor.author | 이재면 | - |
dc.contributor.author | 하성규 | - |
dc.date.accessioned | 2014-12-19T16:34:42Z | - |
dc.date.available | 2014-12-19T16:34:42Z | - |
dc.date.issued | 2012 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89793 | - |
dc.description.abstract | BACKGROUND: Hemodialysis (HD) patients have multiple causes of immune dysfunction and poor immune response to influenza vaccination. We investigated the antibody response rate to a pandemic H1N1/2009 influenza vaccination and clinical parameters influencing the induction of antibody responses in HD patients. METHODS: A total of 114 HD patients were vaccinated with a monovalent adjuvanted H1N1 inactivated influenza vaccine. Titers of neutralizing antibodies were evaluated by hemagglutination inhibition (HI) assay at pre- and 4 weeks after vaccination. Seroconversion was defined as either a pre-vaccination HI titer < 1:10 and a post vaccination HI titer > 1:40 or a pre-vaccination HI titer ≥ 1:10 and a minimum four-fold rise in post-vaccination HI antibody titer. Seventeen out of 114 HD patients (14.9%) tested positive for antibodies against influenza A/H1N1/2009 before vaccination. The remaining 97 baseline sero-negative patients were included in the analysis. RESULTS: Only 30 (30.9%) HD patients had seroconversion 4 weeks after vaccination. The elderly patients, those over 65 years of age, showed significantly lower seroconversion rate compared to younger HD patients (20.5% vs. 39.6%, p = 0.042). Furthermore, patients with hemoglobin values less than 10 g/dL had a significantly lower seroconversion rate compared to those with higher hemoglobin values (20.0 vs. 38.6%, p = 0.049). By multivariate logistic regression analysis, only age ≥65 years (OR = 0.336, 95% confidence interval (CI) 0.116-0.971, p = 0.044) and hemoglobin levels <10 g/dL (OR = 0.315, 95% CI 0.106-0.932, p = 0.037) were independently associated with seroconversion after vaccination. CONCLUSIONS: Our data show that HD patients, especially who are elderly with low hemoglobin levels, are at increased risk for lower seroconversion rate after influenza A/H1N1 vaccination. Further studies are needed to improve the efficacy of vaccination in these high risk patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | BMC NEPHROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antibodies, Viral/blood* | - |
dc.subject.MESH | Comorbidity | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Influenza A Virus, H1N1 Subtype* | - |
dc.subject.MESH | Influenza Vaccines/therapeutic use* | - |
dc.subject.MESH | Influenza, Human/epidemiology | - |
dc.subject.MESH | Influenza, Human/immunology | - |
dc.subject.MESH | Influenza, Human/prevention & control* | - |
dc.subject.MESH | Kidney Failure, Chronic/epidemiology | - |
dc.subject.MESH | Kidney Failure, Chronic/immunology* | - |
dc.subject.MESH | Kidney Failure, Chronic/rehabilitation* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mass Vaccination/utilization | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prevalence | - |
dc.subject.MESH | Renal Dialysis/utilization* | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Risk factors affecting seroconversion after influenza A/H1N1 vaccination in hemodialysis patients. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Sung Jin Moon | - |
dc.contributor.googleauthor | Sang Hun Lee | - |
dc.contributor.googleauthor | Young-Ho Byun | - |
dc.contributor.googleauthor | Gi Young Yun | - |
dc.contributor.googleauthor | Seung Kyu Kim | - |
dc.contributor.googleauthor | Baik-Lin Seong | - |
dc.contributor.googleauthor | Ah Reum Kim | - |
dc.contributor.googleauthor | Eun sun Park | - |
dc.contributor.googleauthor | Hyung-Jong Kim | - |
dc.contributor.googleauthor | Jung Eun Lee | - |
dc.contributor.googleauthor | Sung Kyu Ha | - |
dc.contributor.googleauthor | Jae Myun Lee | - |
dc.contributor.googleauthor | Hyeong-Cheon Park | - |
dc.identifier.doi | 23206898 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01759 | - |
dc.contributor.localId | A03071 | - |
dc.contributor.localId | A04252 | - |
dc.relation.journalcode | J00367 | - |
dc.identifier.eissn | 1471-2369 | - |
dc.identifier.pmid | 23206898 | - |
dc.subject.keyword | Hemodialysis | - |
dc.subject.keyword | Pandemic H1N1/2009 influenza | - |
dc.subject.keyword | Vaccine | - |
dc.subject.keyword | Seroconversion | - |
dc.contributor.alternativeName | Park, Hyeong Cheon | - |
dc.contributor.alternativeName | Lee, Jae Myun | - |
dc.contributor.alternativeName | Ha, Sung Kyu | - |
dc.contributor.affiliatedAuthor | Park, Hyeong Cheon | - |
dc.contributor.affiliatedAuthor | Lee, Jae Myun | - |
dc.contributor.affiliatedAuthor | Ha, Sung Kyu | - |
dc.citation.volume | 13 | - |
dc.citation.startPage | 165 | - |
dc.identifier.bibliographicCitation | BMC NEPHROLOGY, Vol.13 : 165, 2012 | - |
dc.identifier.rimsid | 31907 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.