RG-II from Panax ginseng C.A. Meyer suppresses asthmatic reaction.
In Duk Jung ; Hye Young Kim ; Yeong-Min Park ; Jong Keun Seo ; Seung-Wook Ryu ; Jong-Hwan Park ; Sung Jae Shin ; Hee-ju Park ; Kwang Hee Son ; Su Jung Lee ; Deok Rim Heo ; Hyun Kyu Kang ; Kyung Tae Noh ; Chang-Min Lee ; Jin Wook Park
BMB Reports, Vol.45(2) : 79~84, 2012
In asthma, T helper 2 (T(H)2)-type cytokines such as interleukin (IL)-4, IL-5, and IL-13 are produced by activated CD4(+) T cells. Dendritic cells played an important role in determining the fate of naive T cells into either T(H)1 or T(H)2 cells. We determined whether RG-II regulates the T(H)1/T(H)2 immune response by using an ovalbumin-induced murine model of asthma. RG-II reduced IL-4 production but increased interferon- gamma production, and inhibited GATA-3 gene expression. RG-II also inhibited asthmatic reactions including an increase in the number of eosinophils in bronchoalveolar lavage fluid, an increase in inflammatory cell infiltration in lung tissues, airway luminal narrowing, and airway hyperresponsiveness. This study provides evidence that RG-II plays a critical role in ameliorating the pathogenic process of asthmatic inflammation in mice. These findings provide new insights into the immunotherapeutic role of RG-II in terms of its effects in a murine model of asthma.