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Global gene expression profiling in mouse plasma cell tumor precursor and bystander cells reveals potential intervention targets for plasma cell neoplasia.
DC Field | Value | Language |
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dc.contributor.author | 박은성 | - |
dc.date.accessioned | 2014-12-19T16:33:48Z | - |
dc.date.available | 2014-12-19T16:33:48Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0006-4971 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89765 | - |
dc.description.abstract | Tumor progression usually proceeds through several sequential stages, any of which could be targets for interrupting the progression process if one understood these steps at the molecular level. We extracted nascent plasma cell tumor (PCT) cells from within inflammatory oil granulomas (OG) isolated from IP pristane-injected BALB/c.iMyc(Eμ) mice at 5 different time points during tumor progression. We used laser capture microdissection to collect incipient PCT cells and analyzed their global gene expression on Affymetrix Mouse Genome 430A microarrays. Two independent studies were performed with different sets of mice. Analysis of the expression data used ANOVA and Bayesian estimation of temporal regulation. Genetic pathway analysis was performed using MetaCore (GeneGo) and IPA (Ingenuity). The gene expression profiles of PCT samples and those of undissected OG samples from adjacent sections showed that different genes and pathways were mobilized in the tumor cells during tumor progression, compared with their stroma. Our analysis implicated several genetic pathways in PCT progression, including biphasic (up- and then down-regulation) of the Spp1/osteopontin-dependent network and up-regulation of mRNA translation/protein synthesis. The latter led to a biologic validation study that showed that the AMPK-activating diabetes drug, metformin, was a potent specific PCT inhibitor in vitro. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | BLOOD | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antineoplastic Agents/pharmacology* | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Proliferation/drug effects | - |
dc.subject.MESH | Gene Expression Profiling | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic/drug effects* | - |
dc.subject.MESH | Granuloma, Plasma Cell/drug therapy | - |
dc.subject.MESH | Granuloma, Plasma Cell/metabolism | - |
dc.subject.MESH | Granuloma, Plasma Cell/pathology | - |
dc.subject.MESH | Metformin/pharmacology | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Mice, Transgenic | - |
dc.subject.MESH | Molecular Targeted Therapy | - |
dc.subject.MESH | Neoplasms, Plasma Cell/drug therapy* | - |
dc.subject.MESH | Neoplasms, Plasma Cell/metabolism | - |
dc.subject.MESH | Neoplasms, Plasma Cell/pathology | - |
dc.subject.MESH | Oligonucleotide Array Sequence Analysis | - |
dc.subject.MESH | Osteopontin/genetics | - |
dc.subject.MESH | Osteopontin/metabolism | - |
dc.subject.MESH | Proto-Oncogene Proteins c-myc/genetics | - |
dc.subject.MESH | Proto-Oncogene Proteins c-myc/metabolism | - |
dc.subject.MESH | RNA, Messenger/metabolism | - |
dc.subject.MESH | Stromal Cells/cytology | - |
dc.subject.MESH | Stromal Cells/drug effects* | - |
dc.subject.MESH | Stromal Cells/metabolism | - |
dc.subject.MESH | Tumor Cells, Cultured | - |
dc.title | Global gene expression profiling in mouse plasma cell tumor precursor and bystander cells reveals potential intervention targets for plasma cell neoplasia. | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Institute for Medical Convergence (연의-생공연 메디컬융합연구소) | - |
dc.contributor.googleauthor | Jason LeGrand | - |
dc.contributor.googleauthor | Eun Sung Park | - |
dc.contributor.googleauthor | Hongyang Wang | - |
dc.contributor.googleauthor | Shalu Gupta | - |
dc.contributor.googleauthor | James D. Owens | - |
dc.contributor.googleauthor | Patrick J. Nelson | - |
dc.contributor.googleauthor | Wendy DuBois | - |
dc.contributor.googleauthor | Thomas Bair | - |
dc.contributor.googleauthor | Siegfried Janz | - |
dc.contributor.googleauthor | J. Frederic Mushinski | - |
dc.identifier.doi | 22147894 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01609 | - |
dc.relation.journalcode | J00341 | - |
dc.identifier.eissn | 1528-0020 | - |
dc.identifier.pmid | 22147894 | - |
dc.identifier.url | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271714/ | - |
dc.subject.keyword | Animals | - |
dc.subject.keyword | Antineoplastic Agents/pharmacology* | - |
dc.subject.keyword | Cell Line, Tumor | - |
dc.subject.keyword | Cell Proliferation/drug effects | - |
dc.subject.keyword | Gene Expression Profiling | - |
dc.subject.keyword | Gene Expression Regulation, Neoplastic/drug effects* | - |
dc.subject.keyword | Granuloma, Plasma Cell/drug therapy | - |
dc.subject.keyword | Granuloma, Plasma Cell/metabolism | - |
dc.subject.keyword | Granuloma, Plasma Cell/pathology | - |
dc.subject.keyword | Metformin/pharmacology | - |
dc.subject.keyword | Mice | - |
dc.subject.keyword | Mice, Inbred BALB C | - |
dc.subject.keyword | Mice, Transgenic | - |
dc.subject.keyword | Molecular Targeted Therapy | - |
dc.subject.keyword | Neoplasms, Plasma Cell/drug therapy* | - |
dc.subject.keyword | Neoplasms, Plasma Cell/metabolism | - |
dc.subject.keyword | Neoplasms, Plasma Cell/pathology | - |
dc.subject.keyword | Oligonucleotide Array Sequence Analysis | - |
dc.subject.keyword | Osteopontin/genetics | - |
dc.subject.keyword | Osteopontin/metabolism | - |
dc.subject.keyword | Proto-Oncogene Proteins c-myc/genetics | - |
dc.subject.keyword | Proto-Oncogene Proteins c-myc/metabolism | - |
dc.subject.keyword | RNA, Messenger/metabolism | - |
dc.subject.keyword | Stromal Cells/cytology | - |
dc.subject.keyword | Stromal Cells/drug effects* | - |
dc.subject.keyword | Stromal Cells/metabolism | - |
dc.subject.keyword | Tumor Cells, Cultured | - |
dc.contributor.alternativeName | Park, Eun Sung | - |
dc.contributor.affiliatedAuthor | Park, Eun Sung | - |
dc.citation.volume | 119 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1018 | - |
dc.citation.endPage | 1028 | - |
dc.identifier.bibliographicCitation | BLOOD, Vol.119(4) : 1018-1028, 2012 | - |
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