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The effects of sub-lethal concentrations of silver nanoparticles on inflammatory and stress genes in human macrophages using cDNA microarray analysis

Authors
 Dae-Hyoun Lim ; Jiyoung Jang ; In-Hong Choi ; Kangtaek Lee ; Taegyeong Kang ; Seungjae Kim 
Citation
 Biomaterials, Vol.33(18) : 4690~4699, 2012 
Journal Title
 Biomaterials 
ISSN
 0142-9612 
Issue Date
2012
Abstract
Because of the limited information on size-dependent particle-mediated effects, the present study was conducted to determine if the changes in induced protein expression between 5 nm silver nanoparticles and 100 nm particles after exposure to sub-lethal concentrations. A total of 28,000 cDNA profiles were screened using 5 nm silver nanoparticles and 100 nm silver nanoparticles in a macrophage cell line. Based on results obtained from cDNA microarray we also assessed protein levels of hemeoxygenase-1 (HO-1), heat shock protein-70 (HSP-70) and interleukin-8 (IL-8), which were shown to significantly increase. Together with results obtained using N-acetylcystein (NAC), we were able to clearly show that low level and early stage exposure to 5 nm silver nanoparticles, but not 100 nm, induces expression of IL-8 as well as stress genes against reactive oxygen species (ROS). Therefore, we provide important data to understand and identify the early effects of silver nanoparticles on the immune system.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/89733
DOI
10.1016/j.biomaterials.2012.03.006
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Microbiology
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0142961212002785
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