Cited 14 times in

Alleviation of rheumatoid arthritis by cell-transducible methotrexate upon transcutaneous delivery

Title
 Alleviation of rheumatoid arthritis by cell-transducible methotrexate upon transcutaneous delivery
Authors
 Sang-Won Leea; Ji-Hye Kima; Soo-Kon Leea; Seung-Kyou Leed; Sang-Hwa Yange; Dong-Ho Leed; Tomohiro Morioc; Wook Jin Chaeb; Yong-Beom Parka; Min-Chan Parka
Issue Date
2012
Journal Title
 Biomaterials
ISSN
 0142-9612
Citation
 Biomaterials, Vol.33(5) : 1563~1572, 2012
Abstract
Rheumatoid arthritis (RA) is a systemic autoimmune disease that is initiated and maintained by various inflammatory/immune cells and their cytokines, leading to cartilage degradation and bone erosion. Despite its potent therapeutic efficacy on RA, the oral administration of methotrexate (MTX) provokes serious adverse systemic complications, thus necessitating the local application of MTX. Here, we show that transcutaneous MTX (TC-MTX) can efficiently penetrate joint skin ex vivo and in vivo, and that TC-MTX can significantly improve the various inflammatory symptoms associated with RA. Further, TC-MTX preserved the joint-structures in mice with collagen-induced arthritis (CIA), which was also confirmed by three-dimensional micro-computed tomography scan. TC-MTX markedly decreased the secretion of inflammatory cytokines both in the serum and in inflamed joints of CIA mice. Further, its therapeutic potential is comparable to that of etanercept, a biological agent that block tumor necrosis factor (TNF)-α. Importantly, the systemic cytotoxicity of TC-MTX was not detected. Thus, TC-MTX can be a new therapeutic modality for RA patients without systemic complications.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/89731
DOI
10.1016/j.biomaterials.2011.10.079
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
1. 연구논문 > 1. College of Medicine > Yonsei Biomedical Research Center
Yonsei Authors
사서에게 알리기
  feedback
Link
 http://www.sciencedirect.com/science/article/pii/S0142961211013123
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse