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Enhancement of MSC adhesion and therapeutic efficiency in ischemic heart using lentivirus delivery with periostin

Title
Enhancement of MSC adhesion and therapeutic efficiency in ischemic heart using lentivirus delivery with periostin
Authors
Yun-Hyeong Cho;Min-Ji Cha;Ki-Chul Hwang;Hyuck Moon Kwon;Eunmi Choi;Se-Yeon Lee;Onju Ham;Soyeon Lim;Woochul Chang;Heesang Song;Il-Kwon Kim;Byeong-Wook Song
Issue Date
2012
Journal Title
Biomaterials
ISSN
0142-9612
Citation
Biomaterials, Vol.33(5) : 1376~1385, 2012
Abstract
Many approaches have shown beneficial effects of modified mesenchymal stem cells (MSCs) for treatment of infarcted myocardium, but have primarily focused on enhancing the survival of transplanted MSCs. Here, we show the dual benefits of periostin-overexpressing MSCs (p-MSCs) for infarcted myocardium. P-MSCs led to the marked histological and functional recovery of infarcted myocardium by enhancing survival of MSCs and directly preventing apoptosis of cardiomyocytes. Survival of p-MSCs themselves and cardiomyocytes co-cultured with p-MSCs or treated with the conditioned media from p-MSCs was significantly increased under hypoxic conditions. Decreases in adhesion-related integrins were reversed in cardiomyocytes co-cultured with p-MSCs, followed by increases in p-PI3K and Akt, indicating that periostin activates the PI3K pathway through adhesion-related integrins. When p-MSCs were injected into myocardial infarcted rats, histological pathology and cardiac function were significantly improved compared to MSC-injected controls. Thus, periostin might be a new target of therapeutic treatments using MSCs as carriers for infarcted myocardium.
URI
http://www.sciencedirect.com/science/article/pii/S0142961211013111

http://ir.ymlib.yonsei.ac.kr/handle/22282913/89729
DOI
10.1016/j.biomaterials.2011.10.078
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Life Science
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
1. 연구논문 > 1. College of Medicine > Medical Research Center
1. 연구논문 > 1. College of Medicine > Yonsei Biomedical Research Center
Yonsei Authors
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