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KLF10, transforming growth factor-β-inducible early gene 1, acts as a tumor suppressor.

Authors
 Ki-Duk Song ; Duk-Jung Kim ; Woon Kyu Lee ; Cheol-Heui Yun ; Jong Eun Lee 
Citation
 Biochemical and Biophysical Research Communications, Vol.419(2) : 388~394, 2012 
Journal Title
 Biochemical and Biophysical Research Communications 
ISSN
 0006-291X 
Issue Date
2012
Abstract
Krüppel-like factor 10 (KLF10) has been suggested to be a putative tumor suppressor. In the present study, we generated KLF10 deficient mice to explore this hypothesis in vivo. KLF10 deficient mice exhibited increased predisposition to skin tumorigenesis and markedly accelerated papilloma development after DMBA/TPA treatment. On the other hand, KLF10 deficient keratinocytes showed increased proliferation and apoptosis. In colony formation assays after oncogenic H-Ras transfection, KLF10 deficient mouse embryonic fibroblasts (MEFs) yielded more colonies than wild-type MEFs. Furthermore, KLF10 dose-dependently activated p21(WAF1/CIP1) transcription, which was independent of p53 and Sp1 binding sites in p21(WAF1/CIP1) promoter. This study demonstrates that KLF10 is a tumor suppressor and that it targets p21(WAF1/CIP1) transcription.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/89692
DOI
10.1016/j.bbrc.2012.02.032
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Anatomy
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0006291X12002513
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