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Evaluation of dopamine transporters and D2 receptors in hemiparkinsonian rat brains in vivo using consecutive PET scans of [18F]FPCIT and [18F]fallypride
- Authors
- Jae Yong Choi ; Chul Hoon Kim ; Tae Joo Jeon ; Won Gil Cho ; Jin Suk Lee ; Soo Jin Lee ; Tae Hyun Choi ; Byoung Soo Kim ; Chi Hoon Yi ; Youngbeom Seo ; Dae Ik Yi ; Sang Jin Han ; Minkyung Lee ; Dong Goo Kim ; Jong Doo Lee ; Gwangil An ; Young Hoon Ryu
- Citation
- APPLIED RADIATION AND ISOTOPES, Vol.70(12) : 2689-2694, 2012
- Journal Title
- APPLIED RADIATION AND ISOTOPES
- ISSN
- 0969-8043
- Issue Date
- 2012
- MeSH
- Animals ; Benzamides* ; Corpus Striatum/diagnostic imaging ; Corpus Striatum/metabolism ; Dopamine Plasma Membrane Transport Proteins/metabolism* ; Down-Regulation ; Fluorine Radioisotopes* ; Male ; Oxidopamine ; Parkinsonian Disorders/chemically induced ; Parkinsonian Disorders/physiopathology* ; Positron-Emission Tomography/methods ; Rats ; Rats, Sprague-Dawley ; Receptors, Dopamine D2/metabolism* ; Tomography, Emission-Computed, Single-Photon ; Tropanes* ; Up-Regulation
- Keywords
- Animals ; Benzamides* ; Corpus Striatum/diagnostic imaging ; Corpus Striatum/metabolism ; Dopamine Plasma Membrane Transport Proteins/metabolism* ; Down-Regulation ; Fluorine Radioisotopes* ; Male ; Oxidopamine ; Parkinsonian Disorders/chemically induced ; Parkinsonian Disorders/physiopathology* ; Positron-Emission Tomography/methods ; Rats ; Rats, Sprague-Dawley ; Receptors, Dopamine D2/metabolism* ; Tomography, Emission-Computed, Single-Photon ; Tropanes* ; Up-Regulation
- Abstract
- The aim of this study was to investigate dopaminergic function in unilaterally lesioned 6-OHDA rats by dual PET radioligands: [(18)F]FPCIT (a dopamine transporter imaging radioligand) and [(18)F]fallypride (a dopamine D2 receptors imaging radioligand). As a result, the brain uptake of [(18)F]FPCIT was significantly reduced and that of [(18)F]fallypride was increased in the ipsilateral striatum (lesion side) of the 6-OHDA rats. These findings implicated that dopamine transporter is down-regulated and dopamine D2 receptor is up-regulated in this hemiparkinsonian rat model.
- DOI
- 23041777
- Appears in Collections:
- 1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
- Yonsei Authors
-
Kim, Dong Goo(김동구)
Kim, Chul Hoon(김철훈)
https://orcid.org/0000-0002-7360-429X
Ryu, Young Hoon(유영훈) https://orcid.org/0000-0002-9000-5563
Lee, Min Kyung(이민경)
Lee, Jong Doo(이종두)
Jeon, Tae Joo(전태주) https://orcid.org/0000-0002-7574-6734
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