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Evaluation of dopamine transporters and D2 receptors in hemiparkinsonian rat brains in vivo using consecutive PET scans of [18F]FPCIT and [18F]fallypride

Title
 Evaluation of dopamine transporters and D2 receptors in hemiparkinsonian rat brains in vivo using consecutive PET scans of [18F]FPCIT and [18F]fallypride
Authors
 Jae Yong Choi; Chul Hoon Kim; Tae Joo Jeon; Won Gil Cho; Jin Suk Lee; Soo Jin Lee; Tae Hyun Choi; Byoung Soo Kim; Chi Hoon Yi; Youngbeom Seo; Dae Ik Yi; Sang Jin Han; Minkyung Lee; Dong Goo Kim; Jong Doo Lee; Gwangil An; Young Hoon Ryu
Issue Date
2012
Journal Title
 Applied Radiation and Isotopes
ISSN
 0969-8043
Citation
 Applied Radiation and Isotopes, Vol.70(12) : 2689~2694, 2012
Abstract
The aim of this study was to investigate dopaminergic function in unilaterally lesioned 6-OHDA rats by dual PET radioligands: [(18)F]FPCIT (a dopamine transporter imaging radioligand) and [(18)F]fallypride (a dopamine D2 receptors imaging radioligand). As a result, the brain uptake of [(18)F]FPCIT was significantly reduced and that of [(18)F]fallypride was increased in the ipsilateral striatum (lesion side) of the 6-OHDA rats. These findings implicated that dopamine transporter is down-regulated and dopamine D2 receptor is up-regulated in this hemiparkinsonian rat model.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/89599
DOI
10.1016/j.apradiso.2012.08.005
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pharmacology
1. 연구논문 > 1. College of Medicine > Dept. of Nuclear Medicine
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0969804312004605
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