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Evaluation of dopamine transporters and D2 receptors in hemiparkinsonian rat brains in vivo using consecutive PET scans of [18F]FPCIT and [18F]fallypride

Title
Evaluation of dopamine transporters and D2 receptors in hemiparkinsonian rat brains in vivo using consecutive PET scans of [18F]FPCIT and [18F]fallypride
Authors
Jae Yong Choi;Chul Hoon Kim;Tae Joo Jeon;Won Gil Cho;Jin Suk Lee;Soo Jin Lee;Tae Hyun Choi;Byoung Soo Kim;Chi Hoon Yi;Youngbeom Seo;Dae Ik Yi;Sang Jin Han;Minkyung Lee;Dong Goo Kim;Jong Doo Lee;Gwangil An;Young Hoon Ryu
Issue Date
2012
Journal Title
Applied Radiation and Isotopes
ISSN
0969-8043
Citation
Applied Radiation and Isotopes, Vol.70(12) : 2689~2694, 2012
Abstract
The aim of this study was to investigate dopaminergic function in unilaterally lesioned 6-OHDA rats by dual PET radioligands: [(18)F]FPCIT (a dopamine transporter imaging radioligand) and [(18)F]fallypride (a dopamine D2 receptors imaging radioligand). As a result, the brain uptake of [(18)F]FPCIT was significantly reduced and that of [(18)F]fallypride was increased in the ipsilateral striatum (lesion side) of the 6-OHDA rats. These findings implicated that dopamine transporter is down-regulated and dopamine D2 receptor is up-regulated in this hemiparkinsonian rat model.
URI
http://www.sciencedirect.com/science/article/pii/S0969804312004605

http://ir.ymlib.yonsei.ac.kr/handle/22282913/89599
DOI
10.1016/j.apradiso.2012.08.005
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pharmacology
1. 연구논문 > 1. College of Medicine > Dept. of Nuclear Medicine
Yonsei Authors
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