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CD5-negative blastoid variant mantle cell lymphoma with complex CCND1/IGH and MYC aberrations

Title
CD5-negative blastoid variant mantle cell lymphoma with complex CCND1/IGH and MYC aberrations
Authors
Yoonmi Seok;Juwon Kim;Kyung-A Lee;Jaewoo song;Sue Jung Kim;Seo-Jin Park;Yu Ri Kim;Jong Rak Choi
Issue Date
2012
Journal Title
Annals of Laboratory Medicine
ISSN
2234-3806
Citation
Annals of Laboratory Medicine, Vol.32(1) : 95~98, 2012
Abstract
The coexistence of CCND1/IGH and MYC rearrangements in mantle cell lymphoma (MCL) is a rare finding associated with a very poor prognosis. In this study, a patient with blastoid variant (MCL) is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient only survived for 1 month following diagnosis. Conventional cytogenetic study, FISH, and multicolor FISH (mFISH) demonstrated the involvement of the BCL1/CCND1 locus in a complex translocation, t(3;11)(q25;p15)t(11;14)(q13;q32). In addition, subclonal abnormalities in the 8q24 region, manifested as a t(8;14)(q24;q32)/MYC rearrangement, were identified. To the best of our knowledge, this is the first MCL case in Korea bearing these complex genomic aberrations.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/89511
DOI
10.3343/alm.2012.32.1.95
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Laboratory Medicine
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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