Cited 13 times in

Phase II trial of rituximab plus CVP combination chemotherapy for advanced stage marginal zone lymphoma as a first-line therapy: Consortium for Improving Survival of Lymphoma (CISL) study

Title
Phase II trial of rituximab plus CVP combination chemotherapy for advanced stage marginal zone lymphoma as a first-line therapy: Consortium for Improving Survival of Lymphoma (CISL) study
Authors
Hye Jin Kang;Won Seog Kim;Baek-Yeol Ryoo;Cheolwon Suh;Jinny Park;Jooseop Chung;Hyeon-Seok Eom;Hugh Chul Kim;Sung Yong Oh;Ho Young Kim;Hyo Jung Kim;Gyeong-Won Lee;Se-Ryeon Lee;Jin Seok Kim;Deok-Hwan Yang;Je-Jung Lee;Seok Jin Kim
Issue Date
2012
Journal Title
Annals of Hematology
ISSN
0939-5555
Citation
Annals of Hematology, Vol.91(4) : 543~551, 2012
Abstract
We conducted a multicenter, phase II trial to investigate the efficacy and safety of rituximab plus CVP (R-CVP) combination therapy for patients with previously untreated stage III or IV marginal zone lymphoma (MZL). The treatment consisted of rituximab 375 mg/m2, cyclophosphamide 750 mg/m2 and vincristine 1.4 mg/m2 (maximum 2.0 mg) being given intravenously on day 1 and oral prednisolone 100 mg on days 1–5. The treatment was repeated every 3 weeks and this was continued for six or eight cycles. Forty-two patients were enrolled from 13 institutes in Korea. Among them, two patients were dropped after the first and second cycles of chemotherapy, respectively, without evaluation. The 40 patients received a total of 287 cycles of R-CVP chemotherapy. The overall response rate was 88% (95% CI, 77–98%) with 24 complete responses (60%). The median duration of response was 28.3 months. After a median follow-up of 38.2 months, the estimated 3-year progression-free survival and overall survival were 59% and 95%, respectively. There were 30/287 cycles (11%) and 5/287 cycles (2%) of grade 3 or 4 neutropenia and febrile neutropenia, respectively. The R-CVP regimen can be an effective and tolerable first-line immunochemotherapy regimen for advanced stage MZL.
URI
http://link.springer.com/article/10.1007%2Fs00277-011-1337-6

http://ir.ymlib.yonsei.ac.kr/handle/22282913/89502
DOI
10.1007/s00277-011-1337-6
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
사서에게 알리기
  feedback
Files in This Item:
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse