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Minocycline controls clinical outcomes and inflammatory cytokines in moderate and severe meibomian gland dysfunction.

Title
Minocycline controls clinical outcomes and inflammatory cytokines in moderate and severe meibomian gland dysfunction.
Authors
Hun Lee;Kyung Min;Tae-Im Kim;Eung Kweon Kim
Issue Date
2012
Journal Title
American Journal of Ophthalmology
ISSN
0002-9394
Citation
American Journal of Ophthalmology, Vol.154(6) : 949~957, 2012
Abstract
PURPOSE: To assess clinical outcomes and tear cytokine levels in patients with moderate and severe meibomian gland dysfunction (MGD) after treatment with oral minocycline and artificial tears versus artificial tears only. DESIGN: Prospective, randomized clinical trial. METHODS: Sixty eyes of 60 patients with stage 3 or 4 meibomian gland dysfunction were enrolled. We evaluated the tear film break-up time, Schirmer test results, corneal and conjunctival fluorescein staining results, biomicroscopic examination results of lid margins and meibomian glands, and tear cytokine levels before and after 1 month and 2 months of oral minocycline and artificial tears (group 1) or artificial tears only (group 2). Tear samples were collected and analyzed using a BD Cytometric Bead Array (BD Bioscience, San Jose, California, USA) for detection of interleukin (IL)-1β, IL-6, IL-7, IL-8, IL-12p70, IL-17α, interferon-γ, tumor necrosis factor-α, and monocyte chemotactic protein-1. The Wilcoxon signed-rank test, Mann-Whitney U test, generalized linear model, and linear mixed model were performed. RESULTS: Patients in group 1 showed statistically significant improvement in all clinical signs and symptoms after 1 month and 2 months of treatment. Patients of group 1 showed more significant improvement compared with those in group 2. Patients in group 1 also showed statistically significant reductions in IL-6, IL-1β, IL-17α, tumor necrosis factor-α, and IL-12p70 after 2 months of treatment. CONCLUSIONS: Oral minocycline can provide clinical benefits in treating moderate and severe meibomian gland dysfunction by reducing inflammatory cytokine levels.
URI
http://www.sciencedirect.com/science/article/pii/S0002939412004400

http://ir.ymlib.yonsei.ac.kr/handle/22282913/89433
DOI
10.1016/j.ajo.2012.06.009
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Yonsei Biomedical Research Center
1. 연구논문 > 1. College of Medicine > Dept. of Ophthalmology
Yonsei Authors
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