Cited 35 times in
Sugammadex versus neostigmine reversal of moderate rocuronium-induced neuromuscular blockade in Korean patients
DC Field | Value | Language |
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dc.contributor.author | 심연희 | - |
dc.date.accessioned | 2014-12-18T10:02:09Z | - |
dc.date.available | 2014-12-18T10:02:09Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 2005-6419 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89292 | - |
dc.description.abstract | BACKGROUND: Rapid and complete reversal of neuromuscular blockade (NMB) is desirable at the end of surgery. Sugammadex reverses rocuronium-induced NMB by encapsulation. It is well tolerated in Caucasian patients, providing rapid reversal of moderate (reappearance of T2) rocuronium-induced NMB. We investigated the efficacy and safety of sugammadex versus neostigmine in Korean patients. METHODS: This randomized, safety assessor-blinded trial (NCT01050543) included Korean patients undergoing general anesthesia. Rocuronium 0.6 mg/kg was given prior to intubation with maintenance doses of 0.1-0.2 mg/kg as required. Patients received sugammadex 2.0 mg/kg or neostigmine 50 µg/kg with glycopyrrolate 10 µg/kg to reverse the NMB at the reappearance of T2, after the last rocuronium dose. The primary efficacy endpoint was the time from sugammadex or neostigmine administration to recovery of the train-of-four (TOF) ratio to 0.9. The safety of these medications was also assessed. RESULTS: Of 128 randomized patients, 118 had evaluable data (n = 59 in each group). The geometric mean (95% confidence interval) time to recovery of the TOF ratio to 0.9 was 1.8 (1.6, 2.0) minutes in the sugammadex group and 14.8 (12.4, 17.6) minutes in the neostigmine group (P < 0.0001). Sugammadex was generally well tolerated, with no evidence of residual or recurrence of NMB; four patients in the neostigmine group reported adverse events possibly indicative of inadequate NMB reversal. CONCLUSIONS: Sugammadex was well tolerated and provided rapid reversal of moderate rocuronium-induced NMB in Korean patients, with a recovery time 8.1 times faster than neostigmine. These results are consistent with those reported for Caucasian patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | KOREAN JOURNAL OF ANESTHESIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Sugammadex versus neostigmine reversal of moderate rocuronium-induced neuromuscular blockade in Korean patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Tiffany Woo | - |
dc.contributor.googleauthor | Kyo Sang Kim | - |
dc.contributor.googleauthor | Yon Hee Shim | - |
dc.contributor.googleauthor | Mi Kyeong Kim | - |
dc.contributor.googleauthor | Suk Min Yoon | - |
dc.contributor.googleauthor | Young Jin Lim | - |
dc.contributor.googleauthor | Hong Seuk Yang | - |
dc.contributor.googleauthor | Phillip Phiri | - |
dc.contributor.googleauthor | Jin Young Cho | - |
dc.identifier.doi | 10.4097/kjae.2013.65.6.501 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02196 | - |
dc.relation.journalcode | J01963 | - |
dc.identifier.eissn | 2005-7563 | - |
dc.identifier.pmid | 24427455 | - |
dc.subject.keyword | Caucasian | - |
dc.subject.keyword | Korean | - |
dc.subject.keyword | Neostigmine | - |
dc.subject.keyword | Neuromuscular blockade | - |
dc.subject.keyword | Rocuronium | - |
dc.subject.keyword | Sugammadex | - |
dc.contributor.alternativeName | Shim, Yon Hee | - |
dc.contributor.affiliatedAuthor | Shim, Yon Hee | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 65 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 501 | - |
dc.citation.endPage | 507 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF ANESTHESIOLOGY, Vol.65(6) : 501-507, 2013 | - |
dc.identifier.rimsid | 34510 | - |
dc.type.rims | ART | - |
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