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Prolonged clinical benefit from the maintenance hormone therapy in patients with metastatic breast cancer

Title
 Prolonged clinical benefit from the maintenance hormone therapy in patients with metastatic breast cancer
Authors
 Seungtaek Lim; Soohyeon Lee; Joohyuk Sohn; Hye Jin Choi; Joo-Hang Kim; Seho Park; SeungIl Kim; Byeong-Woo Park; Jungwoo Han
Issue Date
2013
Journal Title
 Breast
ISSN
 0960-9776
Citation
 Breast, Vol.22(6) : 1205~1209, 2013
Abstract
Objective We investigated the efficacy of maintenance hormone therapy (MHT), which was given to hormone positive metastatic breast cancer (MBC) patients in non-progression status to the previous chemotherapy. Methods This study retrospectively analyzed 76 MBC patients who had been treated with MHT from 2006 to 2010 at a single institute. Results For the 76 patients reviewed, the median progression free survival (PFS) to MHT was 14.4 months (95% CI, 11.6–17.3). Prolonged PFS was associated with less previous palliative chemotherapy, fewer metastatic sites, and the absence of visceral metastasis in univariate analysis. Multivariate analysis showed that only the number of previous palliative chemotherapy (HR 1.73, 95% CI, 1.00–2.98; P = 0.04) remained as a significant variable. MHT was generally well tolerated.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/88927
DOI
10.1016/j.breast.2013.08.013
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
1. 연구논문 > 1. College of Medicine > Dept. of Pediatrics
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0960977613002476
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