Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer

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Authors: Hyunsoo Chung ; Hanbyoul Cho ; Candice Perry ; Jaekyung Song ; Kris Ylaya ; Heejeong Lee ; Jae-Hoon Kim

MeSH: Adult ; Aged ; Cervical Intraepithelial Neoplasia/metabolism* ; Cervical Intraepithelial Neoplasia/mortality ; Cervical Intraepithelial Neoplasia/pathology ; Disease-Free Survival ; Down-Regulation ; Female ; Gene Expression* ; Gene Expression Regulation, Neoplastic ; Humans ; Kaplan-Meier Estimate ; Middle Aged ; Multivariate Analysis ; Neoplasm Staging ; Prognosis ; Protein Disulfide-Isomerases/genetics* ; Protein Disulfide-Isomerases/metabolism ; Protein Transport ; Tissue Array Analysis ; Uterine Cervical Neoplasms/metabolism* ; Uterine Cervical Neoplasms/mortality ; Uterine Cervical Neoplasms/pathology ; Young Adult

Keywords: Cervical cancer ; ERp57 ; immunohistochemistry ; survival ; tissue microarray

Abstract: OBJECTIVE:
We investigated the clinical significance of ERp57 in the progression of cervical cancer.
METHODS:
mRNA and protein expression of ERp57 in cervical neoplasias were examined.
RESULTS:
ERp57 mRNA expression was significantly decreased in cervical cancers. Immunohistochemistry revealed that ERp57 expression in 123 cervical cancers was down-regulated compared to cervical intraepithelial neoplasias or normal tissues (p < 0.001). Low ERp57 expression was significantly associated with worse overall survival (HR = 12.19, p = 0.018).
CONCLUSIONS:
Low ERp57 expression independently predicts a poor outcome for patients with cervical cancer, supporting the notion that ERp57 may be a promising novel cancer target.

Full Text: http://informahealthcare.com/doi/abs/10.3109/1354750X.2013.827742

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

Yonsei Authors: Kim, Jae Hoon(김재훈) https://orcid.org/0000-0001-6599-7065
Cho, Hanbyoul(조한별) https://orcid.org/0000-0002-6177-1648

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