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Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer

Authors
 Hyunsoo Chung ; Hanbyoul Cho ; Jae-Hoon Kim ; Heejeong Lee ; Kris Ylaya ; Jaekyung Song ; Candice Perry 
Citation
 Biomarkers, Vol.18(7) : 573~579, 2013 
Journal Title
 Biomarkers 
ISSN
 1354-750X 
Issue Date
2013
Abstract
OBJECTIVE: We investigated the clinical significance of ERp57 in the progression of cervical cancer. METHODS: mRNA and protein expression of ERp57 in cervical neoplasias were examined. RESULTS: ERp57 mRNA expression was significantly decreased in cervical cancers. Immunohistochemistry revealed that ERp57 expression in 123 cervical cancers was down-regulated compared to cervical intraepithelial neoplasias or normal tissues (p < 0.001). Low ERp57 expression was significantly associated with worse overall survival (HR = 12.19, p = 0.018). CONCLUSIONS: Low ERp57 expression independently predicts a poor outcome for patients with cervical cancer, supporting the notion that ERp57 may be a promising novel cancer target.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/88675
DOI
10.3109/1354750X.2013.827742
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Obstetrics & Gynecology
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Link
 http://informahealthcare.com/doi/abs/10.3109/1354750X.2013.827742
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