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Autophagy controls an intrinsic host defense to bacteria by promoting epithelial cell survival: a murine model

Title
Autophagy controls an intrinsic host defense to bacteria by promoting epithelial cell survival: a murine model
Authors
Sun-Young Chang;Se-Na Lee;Mi-Na Kweon;Chihiro Sasakawa;Michinaga Ogawa;Hyun-Jeong Ko;Joo-Heon Yoon;Dong Wook Kim;Jin-Young Yang
Issue Date
2013
Journal Title
PLoS One
ISSN
1932-6203
Citation
PLoS One, Vol.8(11) : e81095, 2013
Abstract
Cell death is a critical host response to regulate the fate of bacterial infections, innate immune responses, and ultimately, disease outcome. Shigella spp. invade and colonize gut epithelium in human and nonhuman primates but adult mice are naturally resistant to intra-gastric Shigella infection. In this study, however, we found Shigella could invade the terminal ileum of the mouse small intestine by 1 hour after infection and be rapidly cleared within 24 h. These early phase events occurred shortly after oral infection resulting in epithelial shedding, degranulation of Paneth cells, and cell death in the intestine. During this process, autophagy proceeded without any signs of inflammation. In contrast, blocking autophagy in epithelial cells enhanced host cell death, leading to tissue destruction and to inflammation, suggesting that autophagic flow relieves cellular stress associated with host cell death and inflammation. Herein we propose a new concept of “epithelial barrier turnover” as a general intrinsic host defense mechanism that increases survival of host cells and inhibits inflammation against enteric bacterial infections, which is regulated by autophagy.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/88512
DOI
10.1371/journal.pone.0081095
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Otorhinolaryngology
Yonsei Authors
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