Cited 10 times in
Apoptosis signal-regulating kinase-1 aggravates ROS-mediated striatal
DC Field | Value | Language |
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dc.contributor.author | 김경환 | - |
dc.contributor.author | 김현우 | - |
dc.contributor.author | 이종은 | - |
dc.contributor.author | 전소영 | - |
dc.contributor.author | 조경주 | - |
dc.date.accessioned | 2014-12-18T09:36:30Z | - |
dc.date.available | 2014-12-18T09:36:30Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88490 | - |
dc.description.abstract | Apoptosis signal-regulating kinase-1 (ASK1), an early signaling element in the cell death pathway, has been suggested to participate in the pathology of neurodegenerative diseases, which may be associated with environmental factors that impact the diseases. Although it is not entirely elucidated, 3-nitropropionic acid (3-NP) provokes mitochondrial dysfunction and selectively forms striatal lesions similar to those found in Huntington’s disease. The current study investigated whether ASK1 is involved in striatal pathology following chronic systemic infusion of 3-NP. The results show that ASK1 acts as a primary mediator of there active oxygen species (ROS) cell death signal cascade in the 3-NP-damaged striatal region by disrupting the positive feedback cycle. In 3-NP-infused striatal lesions, ROS increased ASK1. Superoxide dismutase transgenic (SOD-tg) mice reduced ASK1by scavenging ROS, and reduction of ASK1leads to a reduction in cell death. However, ASK1 down-regulation in 3-NP infusion mice also decreased striatal cell death without scavenging ROS. In contrast decreasing cell death by si-ASK1 treatment along with 3-NP in both SOD tg and wild-type mice (wt), cell death rebounded when ASK1 peptide was added to SOD tg mice. The present study suggests that ROS-inducing ASK1 may be an important step in the pathogenesis of 3-NP infused striatal lesions in murine brains. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Apoptosis signal-regulating kinase-1 aggravates ROS-mediated striatal | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anatomy (해부학) | - |
dc.contributor.googleauthor | Kyoung Joo Cho | - |
dc.contributor.googleauthor | Hyun Woo Kim | - |
dc.contributor.googleauthor | So Yeong Cheon | - |
dc.contributor.googleauthor | Jong Eun Lee | - |
dc.contributor.googleauthor | Gyung Whan Kim | - |
dc.identifier.doi | 10.1016/j.bbrc.2013.08.103 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00310 | - |
dc.contributor.localId | A03522 | - |
dc.contributor.localId | A03804 | - |
dc.contributor.localId | A03146 | - |
dc.contributor.localId | A01125 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | Apoptosis signal-regulating kinase 1 ; 3-Nitropropionic acid ; siRNA ; Superoxide dismutase | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X13014769 | - |
dc.subject.keyword | Apoptosis signal-regulating kinase 1 | - |
dc.subject.keyword | 3-Nitropropionic acid | - |
dc.subject.keyword | siRNA | - |
dc.subject.keyword | Superoxide dismutase | - |
dc.contributor.alternativeName | Kim, Gyung Whan | - |
dc.contributor.alternativeName | Kim, Hyun Woo | - |
dc.contributor.alternativeName | Lee, Jong Eun | - |
dc.contributor.alternativeName | Cheon, So Yeong | - |
dc.contributor.alternativeName | Cho, Kyuong Joo | - |
dc.contributor.affiliatedAuthor | Kim, Gyung Whan | - |
dc.contributor.affiliatedAuthor | Cheon, So Yeong | - |
dc.contributor.affiliatedAuthor | Cho, Kyuong Joo | - |
dc.contributor.affiliatedAuthor | Lee, Jong Eun | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Woo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 441 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 280 | - |
dc.citation.endPage | 285 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.441(2) : 280-285, 2013 | - |
dc.identifier.rimsid | 34061 | - |
dc.type.rims | ART | - |
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