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Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia

Authors
 Ok-Hee Lee ; Jayoung Kim ; Ji Hoe Heo ; Hyo Suk Nam ; Youngsok Choi ; Soo-Kyung Bae ; Eun Hee Kim ; Hyunji Lee ; Jin-Moo Kim 
Citation
 Biochemical and Biophysical Research Communications, Vol.438(2) : 388~394, 2013 
Journal Title
 Biochemical and Biophysical Research Communications 
ISSN
 0006-291X 
Issue Date
2013
Abstract
Sirtuin 6 (SIRT6) belongs to the sirtuin family of NAD+-dependent deacetylases and has been implicated in the regulation of metabolism, inflammation, and aging. Here, we found that SIRT6 was predominantly expressed in neuronal cells throughout the entire brain. Ischemia models using transient middle cerebral artery occlusion in rats and oxygen/glucose deprivation (OGD) in SH-SY5Y neuronal cells showed that ischemia reduced SIRT6 expression and induced the release of high mobility group box-1 (HMGB1) from cell nuclei. The reduced expression of SIRT6 via treatment with SIRT6 siRNA dramatically enhanced the OGD-induced release of HMGB1 in SH-SY5Y cells. Together, our data suggest that SIRT6 may serve as a potential therapeutic target for HMGB1-mediated inflammation after cerebral ischemia.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/88485
DOI
10.1016/j.bbrc.2013.07.085
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Yonsei Biomedical Research Center
1. 연구논문 > 5. Research Institutes > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease
1. 연구논문 > 1. College of Medicine > Dept. of Neurology
1. 연구논문 > 1. College of Medicine > Medical Research Center
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0006291X13012473
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