Flecainide-Associated Bradycardia-Dependent Torsade de Pointes: Another Potential Mechanism of Proarrhythmia
HAN SANG KIM ; HUI-NAM PAK ; SUNG SOON KIM ; JONG SEOUNG PARK
PACE - Pacing and Clinical Electrophysiology, Vol.36(3) : e84~e86, 2013
PACE - Pacing and Clinical Electrophysiology
Although flecainide has a risk of proarrhythmia in patients with structural heart disease, its mechanism has been mainly ascribed to use-dependency and a rapid ventricular response to organized atrial tachyarrhythmias or to ventricular tachycardia. We present a patient who experienced recurrent syncope due to bradycardia-dependent torsade de pointes (TdP) associated with flecainide-related bradycardia and QT prolongation. Bradycardia-dependent TdP with QT prolongation can be considered as one of mechanisms of flecainide-induced proarrhythmia.