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Flecainide-Associated Bradycardia-Dependent Torsade de Pointes: Another Potential Mechanism of Proarrhythmia

Authors
 HAN SANG KIM ; HUI-NAM PAK ; SUNG SOON KIM ; JONG SEOUNG PARK 
Citation
 PACE - Pacing and Clinical Electrophysiology, Vol.36(3) : e84~e86, 2013 
Journal Title
 PACE - Pacing and Clinical Electrophysiology 
ISSN
 0147-8389 
Issue Date
2013
Abstract
Although flecainide has a risk of proarrhythmia in patients with structural heart disease, its mechanism has been mainly ascribed to use-dependency and a rapid ventricular response to organized atrial tachyarrhythmias or to ventricular tachycardia. We present a patient who experienced recurrent syncope due to bradycardia-dependent torsade de pointes (TdP) associated with flecainide-related bradycardia and QT prolongation. Bradycardia-dependent TdP with QT prolongation can be considered as one of mechanisms of flecainide-induced proarrhythmia.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/88480
DOI
10.1111/j.1540-8159.2010.02935.x
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pharmacology
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1111/j.1540-8159.2010.02935.x/abstract
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