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Study of peripheral BRAFV600E mutation as a possible novel marker for papillary thyroid carcinomas

Title
Study of peripheral BRAFV600E mutation as a possible novel marker for papillary thyroid carcinomas
Authors
Jin Young Kwak;Jong Ju Jeong;Woong Youn Chung;Eun Kyung Kim;Seo–Jin Park;Jong Rak Choi;Seulkee Park;Sang–Wook Kang
Issue Date
2013
Journal Title
Head & Neck
ISSN
1043-3074
Citation
Head & Neck, Vol.35(11) : 1630~1633, 2013
Abstract
BACKGROUND: The BRAF(V600E) mutation can be detected peripherally in the serum of patients with thyroid cancer. The purpose of this study was to establish the value of detecting the peripheral BRAF(V600E) mutation as a serum tumor marker in this population. METHODS: In this study, we obtained 94 serum samples from patients with papillary thyroid cancer positive for the BRAF(V600E) mutation in the tumor itself. The serum samples were analyzed for BRAF(V600E) mutation using real-time polymerase chain reaction (PCR). RESULTS: Sixty-seven patients (71.3%) had papillary thyroid microcarcinoma and 26 patients (27.7%) had underlying lymphocytic thyroiditis. Forty-three patients (45.7%) were found to have stage III or stage IV thyroid cancer. None of the patients had a detectable serum BRAF(V600E) mutation. CONCLUSION: We were unable to identify peripheral BRAF(V600E) mutations in patients with papillary thyroid cancer using real-time PCR. Further studies will be needed to validate our results using various diagnostic methods.
URI
http://onlinelibrary.wiley.com/doi/10.1002/hed.23195/abstract

http://ir.ymlib.yonsei.ac.kr/handle/22282913/88445
DOI
10.1002/hed.23195
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
1. 연구논문 > 1. College of Medicine > Dept. of Laboratory Medicine
1. 연구논문 > 1. College of Medicine > Dept. of Radiology
Yonsei Authors
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