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The Clinical Measures Associated with C-peptide Decline in Patients with Type 1 Diabetes over 15 Years

Title
 The Clinical Measures Associated with C-peptide Decline in Patients with Type 1 Diabetes over 15 Years
Authors
 Tae Ho Lee; Ah Reum Kwon; Duk Hee Kim; Ho Seong Kim; Hyun Wook Chae; Ye Jin Kim
Issue Date
2013
Journal Title
 Journal of Korean Medical Science
ISSN
 1011-8934
Citation
 Journal of Korean Medical Science, Vol.28(9) : 1340~1344, 2013
Abstract
This study was done to characterize the natural course of C-peptide levels in patients with type 1 diabetes and identify distinguishing characters among patients with lower rates of C-peptide decline. A sample of 95 children with type 1 diabetes was analyzed to retrospectively track serum levels of C-peptide, HbA1c, weight, BMI, and diabetic complications for the 15 yr after diagnosis. The clinical characteristics were compared between the patients with low and high C-peptide levels, respectively. The average C-peptide level among all patients was significantly reduced five years after diagnosis (P < 0.001). The incidence of diabetic ketoacidosis was significantly lower among the patients with high levels of C-peptide (P = 0.038). The body weight and BMI standard deviation scores (SDS) 15 yr after diagnosis were significantly higher among the patients with low C-peptide levels (weight SDS, P = 0.012; BMI SDS, P = 0.044). In conclusion, C-peptide level was significantly decreased after 5 yr from diagnosis. Type 1 diabetes patients whose beta-cell functions were preserved might have low incidence of diabetic ketoacidosis. The declines of C-peptide level after diagnosis in type 1 diabetes may be associated with changes of body weight and BMI.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/88435
DOI
10.3346/jkms.2013.28.9.1340
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pediatrics
Yonsei Authors
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