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Reduction of the CD16(-)CD56(bright) NK Cell Subset Precedes NK Cell Dysfunction in Prostate Cancer
DC Field | Value | Language |
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dc.contributor.author | 구교철 | - |
dc.contributor.author | 김광현 | - |
dc.contributor.author | 나군호 | - |
dc.contributor.author | 신태영 | - |
dc.contributor.author | 심두희 | - |
dc.contributor.author | 윤호근 | - |
dc.contributor.author | 이샛별 | - |
dc.contributor.author | 이재면 | - |
dc.contributor.author | 홍성준 | - |
dc.date.accessioned | 2014-12-18T09:33:08Z | - |
dc.date.available | 2014-12-18T09:33:08Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88382 | - |
dc.description.abstract | BACKGROUND: Natural cytotoxicity, mediated by natural killer (NK) cells plays an important role in the inhibition and elimination of malignant tumor cells. To investigate the immunoregulatory role of NK cells and their potential as diagnostic markers, NK cell activity (NKA) was analyzed in prostate cancer (PCa) patients with particular focus on NK cell subset distribution. METHODS: Prospective data of NKA and NK cell subset distribution patterns were measured from 51 patients initially diagnosed with PCa and 54 healthy controls. NKA was represented by IFN-γ levels after stimulation of the peripheral blood with Promoca®. To determine the distribution of NK cell subsets, PBMCs were stained with fluorochrome-conjugated monoclonal antibodies. Then, CD16(+)CD56(dim) and CD16(-)CD56(bright) cells gated on CD56(+)CD3(-) cells were analyzed using a flow-cytometer. RESULTS: NKA and the proportion of CD56(bright) cells were significantly lower in PCa patients compared to controls (430.9 pg/ml vs. 975.2 pg/ml and 2.3% vs. 3.8%, respectively; p<0.001). Both tended to gradually decrease according to cancer stage progression (p for trend = 0.001). A significantly higher CD56(dim)-to-CD56(bright) cell ratio was observed in PCa patients (41.8 vs. 30.3; p<0.001) along with a gradual increase according to cancer stage progression (p for trend = 0.001), implying a significant reduction of CD56(bright) cells in relation to the alteration of CD56(dim) cells. The sensitivity and the specificity of NKA regarding PCa detection were 72% and 74%, respectively (best cut-off value at 530.9 pg/ml, AUC = 0.786). CONCLUSIONS: Reduction of CD56(bright) cells may precede NK cell dysfunction, leading to impaired cytotoxicity against PCa cells. These observations may explain one of the mechanisms behind NK cell dysfunction observed in PCa microenvironment and lend support to the development of future cancer immunotherapeutic strategies. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Biomarkers, Tumor/immunology | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism* | - |
dc.subject.MESH | CD56 Antigen/metabolism* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | GPI-Linked Proteins/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Killer Cells, Natural/immunology | - |
dc.subject.MESH | Killer Cells, Natural/metabolism* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prostatic Neoplasms/immunology | - |
dc.subject.MESH | Prostatic Neoplasms/pathology* | - |
dc.subject.MESH | ROC Curve | - |
dc.subject.MESH | Receptors, IgG/metabolism* | - |
dc.title | Reduction of the CD16(-)CD56(bright) NK Cell Subset Precedes NK Cell Dysfunction in Prostate Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨기과학) | - |
dc.contributor.googleauthor | Kyo Chul Koo | - |
dc.contributor.googleauthor | Doo Hee Shim | - |
dc.contributor.googleauthor | Chang Mo Yang | - |
dc.contributor.googleauthor | Saet-Byul Lee | - |
dc.contributor.googleauthor | Shi Mun Kim | - |
dc.contributor.googleauthor | Tae Young Shin | - |
dc.contributor.googleauthor | Kwang Hyun Kim | - |
dc.contributor.googleauthor | Ho Geun Yoon | - |
dc.contributor.googleauthor | Koon Ho Rha | - |
dc.contributor.googleauthor | Jae Myun Lee | - |
dc.contributor.googleauthor | Sung Joon Hong | - |
dc.identifier.doi | 10.1371/journal.pone.0078049 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00188 | - |
dc.contributor.localId | A01227 | - |
dc.contributor.localId | A02168 | - |
dc.contributor.localId | A02191 | - |
dc.contributor.localId | A02625 | - |
dc.contributor.localId | A02845 | - |
dc.contributor.localId | A03071 | - |
dc.contributor.localId | A04402 | - |
dc.contributor.localId | A00319 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 24223759 | - |
dc.subject.keyword | Biomarkers, Tumor/immunology | - |
dc.subject.keyword | Biomarkers, Tumor/metabolism* | - |
dc.subject.keyword | CD56 Antigen/metabolism* | - |
dc.subject.keyword | Case-Control Studies | - |
dc.subject.keyword | GPI-Linked Proteins/metabolism | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Killer Cells, Natural/immunology | - |
dc.subject.keyword | Killer Cells, Natural/metabolism* | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Prostatic Neoplasms/immunology | - |
dc.subject.keyword | Prostatic Neoplasms/pathology* | - |
dc.subject.keyword | ROC Curve | - |
dc.subject.keyword | Receptors, IgG/metabolism* | - |
dc.contributor.alternativeName | Koo, Kyo Chul | - |
dc.contributor.alternativeName | Kim, Kwang Hyun | - |
dc.contributor.alternativeName | Rha, Koon Ho | - |
dc.contributor.alternativeName | Shin, Tae Young | - |
dc.contributor.alternativeName | Shim, Doo Hee | - |
dc.contributor.alternativeName | Yoon, Ho Geun | - |
dc.contributor.alternativeName | Lee, Saet Byul | - |
dc.contributor.alternativeName | Lee, Jae Myun | - |
dc.contributor.alternativeName | Hong, Sung Joon | - |
dc.contributor.affiliatedAuthor | Koo, Kyo Chul | - |
dc.contributor.affiliatedAuthor | Rha, Koon Ho | - |
dc.contributor.affiliatedAuthor | Shin, Tae Young | - |
dc.contributor.affiliatedAuthor | Shim, Doo Hee | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Geun | - |
dc.contributor.affiliatedAuthor | Lee, Saet Byul | - |
dc.contributor.affiliatedAuthor | Lee, Jae Myun | - |
dc.contributor.affiliatedAuthor | Hong, Sung Joon | - |
dc.contributor.affiliatedAuthor | Kim, Kwang Hyun | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 8 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | e78049 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.8(11) : e78049, 2013 | - |
dc.identifier.rimsid | 32477 | - |
dc.type.rims | ART | - |
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