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Immunostimulatory Effects of Silica Nanoparticles in Human Monocytes

Authors
 양은정 ; 최인홍 
Citation
 Immune NetWork, Vol.13(3) : 94~101, 2013 
Journal Title
 Immune NetWork 
ISSN
 1598-2629 
Issue Date
2013
Abstract
Amorphous silica particles, whose applications are increasing in many biomedical fields, are known to be less toxic than crystalline silica. In this study, the inflammatory effects of amorphous silica nanoparticles were investigated using 30-nm amorphous silica nanoparticles and human peripheral blood mononuclear cells (PBMCs) or purified monocytes. As a result, production of IL-1β and IL-8 were increased. In addition, the mitochondrial reactive oxygen species (ROS) was detected, which may lead to mitochondrial membrane disruption. Most importantly, inflammasome formation was observed. Therefore, these results provide immunological information about amorphous silica nanoparticles and suggest that amorphous silica nanoparticles can evoke innate immune reactions in human monocytes through production of IL-1β and IL-8.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/88229
DOI
10.4110/in.2013.13.3.94
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Microbiology
Yonsei Authors
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