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The effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors on vertical bone regeneration in the marginal portion of the peri-implant

Authors
 심준성 
Citation
 Oral Surgery Oral Medicine Oral Pathology Oral Radiology, Vol.115(6) : e24~e31, 2013 
Journal Title
 Oral Surgery Oral Medicine Oral Pathology Oral Radiology 
ISSN
 2212-4403 
Issue Date
2013
Abstract
OBJECTIVES: The aim of this study was to evaluate the effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors (rhVEGFs) on vertical bone regeneration in the marginal portion of the peri-implant. STUDY DESIGN: Supra-alveolar defects were created in 3 male beagle dogs. Each animal received 8 implants that were either coated with a single growth factor (rhBMP-2) or combined growth factors (rhBMP-2 + rhVEGF), or an anodized implant (the control group). The amount of the vertical bone regeneration, the bone-implant contact, and the intrathread bone density were investigated using histomorphometric analysis at 8 weeks. RESULTS: The bone morphogenetic protein (BMP) group and the BMP-VEGF group showed vertical alveolar bone regeneration and enhanced bone-implant contact in the microthread compared with the control group (P < .05). CONCLUSIONS: Anodized implants coated with rhBMP-2 and rhBMP - 2 + rhVEGF can induce vertical alveolar bone regeneration, but the combined effect of rhBMP-2 and rhVEGF was not verified.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/88221
DOI
10.1016/j.oooo.2011.10.040
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Prosthodontics
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S2212440312001745
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