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Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: A birth cohort study(COCOA)

Title
 Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: A birth cohort study(COCOA) 
Authors
 Youn Ho Shin ; Jinho Yu ; Soo-Jong Hong ; Hye-Sung Won ; Pil Ryang Lee ; Hee Jin Park ; Kyung-Ju Lee ; Ja-Young Kwon ; Soo-Young Oh ; Suk-Joo Choi ; Bong Sung Kim ; Hyeon-Jong Yang ; Dong In Suh ; Gwang Cheon Jang ; Soo Young Lee ; So-Yeon Lee ; Dae Jin Song ; Woo Kyung Kim ; Jung Yeon Shim ; Hyo-Bin Kim ; Byoung-Ju Kim ; Ji-Won Kwon ; Ju-Hee Seo ; Hyung Young Kim ; Young-Ho Jung ; Song-I Yang ; Eun Lee ; Seo-Ah Hong ; Kangmo Ahn ; Kyung Won Kim 
Issue Date
2013
Journal Title
 Korean Journal of Pediatrics 
ISSN
 1738-1061 
Citation
 Korean Journal of Pediatrics, Vol.56(10) : 439~445, 2013 
Abstract
Purpose: Previous studies suggest that the concentration of 25-hydroxyvitamin D [25(OH)D] in cord blood may show an inverse association with respiratory tract infections (RTI) during childhood. The aim of the present study was to examine the influence of 25(OH)D concentrations in cord blood on infant RTI in a Korean birth cohort. Methods: The levels of 25(OH)D in cord blood obtained from 525 Korean newborns in the prospective COhort for Childhood Origin of Asthma and allergic diseases were examined. The primary outcome variable of interest was the prevalence of RTI at 6-month follow-up, as diagnosed by pediatricians and pediatric allergy and pulmonology specialists. RTI included acute nasopharyngitis, rhinosinusitis, otitis media, croup, tracheobronchitis, bronchiolitis, and pneumonia. Results: The median concentration of 25(OH)D in cord blood was 32.0 nmol/L (interquartile range, 21.4 to 53.2). One hundred and eighty neonates (34.3%) showed 25(OH)D concentrations less than 25.0 nmol/L, 292 (55.6%) showed 25(OH)D concentrations of 25.0–74.9 nmol/L, and 53 (10.1%) showed concentrations of ≥75.0 nmol/L. Adjusting for the season of birth, multivitamin intake during pregnancy, and exposure to passive smoking during pregnancy, 25(OH)D concentrations showed an inverse association with the risk of acquiring acute nasopharyngitis by 6 months of age (P for trend= 0.0004). Conclusion: The results show that 89.9% of healthy newborns in Korea are born with vitamin D insufficiency or deficiency (55.6% and 34.3%, respectively). Cord blood vitamin D insufficiency or deficiency in healthy neonates is associated with an increased risk of acute nasopharyngitis by 6 months of age. More time spent outdoors and more intensified vitamin D supplementation for pregnant women may be needed to prevent the onset of acute nasopharyngitis in infants.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/88194
DOI
10.3345/kjp.2013.56.10.439
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Obstetrics & Gynecology
1. 연구논문 > 1. College of Medicine > Dept. of Pediatrics
Yonsei Authors
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