Clinical differences in Clostridium diffi cile infection based on age:A multicenter study
Hyung Hun Kim ; You Sun Kim ; Kyuchan Huh ; Chang Hwan Choi ; Jae Hee Cheon ; Sung-Ae Jung ; Byung-Ik Jang ; Sang Heon Lee ; Kang-Moon Lee ; Chang Soo Eun ; Byong Duk Ye ; Suk-Kyun Yang ; Sung Jae Shin ; Hyun Joo Song ; Young-Sook Park ; Hyun-Soo Kim ; Hyunsoo Kim ; Joo Sung Kim ; Won Ho Kim ; Young-Ho Kim ; Dong Soo Han
Scandinavian Journal of Infectious Diseases, Vol.46(1) : 46~51, 2013
Scandinavian Journal of Infectious Diseases
Advancing age is a well-known risk factor for Clostridium difficile infection (CDI). However, age-specific clinical differences in CDI are uncertain. A retrospective comparative analysis was performed based on age in 1367 patients with CDI in Korea. Most clinical features were similar in the two age groups studied, however malignancy was more common in the older group (age ≥ 65 y) (p < 0.001), while chemotherapy and transplantation were more common in the younger group (age < 65 y) (p < 0.001). Endoscopic examinations were more commonly performed in the older group (p = 0.010), which had a high positive predictive value (88.3%). More patients recovered from CDI without specific antibiotic treatment in the younger group than in the older group (p < 0.001). Although advancing age is an important risk factor for CDI, the clinical features of younger patients are similar to those of the older patient population.