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폐이식에서 체외 폐 관류 모델의 적용

Other Titles
 Ex vivo Lung Perfusion Model in Lung Transplantation 
Authors
 함석진 ; 백효채 ; 김나영 ; 김동욱 ; 이두연 
Citation
 Journal of the Korean Society for Transplantation (대한이식학회지), Vol.27(3) : 100~106, 2013 
Journal Title
 Journal of the Korean Society for Transplantation (대한이식학회지) 
ISSN
 1598-1711 
Issue Date
2013
Abstract
Background Lung transplantation (LTx) is an effective treatment for end stage lung disease. However, the shortage of donor lungs has been a major limiting factor to increase the number of LTx. Ex vivo lung perfusion (EVLP) is a currently approved method to evaluate lung function and to repair donor lung with poor function. The purpose of this study was to develop EVLP system in pig model and to maintain lung function during 4 hours of EVLP. Methods Bilateral lung blocks were harvested from five 40 kg pigs. These blocks were applied in EVLP perfused with 37℃ Steen solution. We performed arterial blood gas (ABG) analyses before death and also every 1 hour for 4 hours after application of EVLP and calculated oxygen capacities (OC) using the results of ABG. We also calculated pulmonary vascular resistance (PVR) and peak airway pressure (PAP) every 1 hour for 4 hours. After EVLP procedure, we excised specimens for pathologic review. Results We found that OC gradually decreased during the 4 hour period of EVLP; however, no statistically significant difference was obtained. PVR declined sharply after 1 hour of EVLP (P=0.031) and then remained constant for 3 hours. PAP significantly increased after 3 hours (P<0.0001). Pathologic investigations revealed various findings from normal lung to severe pulmonary edema. Conclusions On the results of this study, we could preserve the lung function for 4 hours using EVLP. We conclude that application of EVLP in clinical setting can make more donor lungs available for LTx. However, we also understand that more studies and training are needed in clinical practice.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/88147
DOI
10.4285/jkstn.2013.27.3.100
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Thoracic & Cardiovascular Surgery
Yonsei Authors
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