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Aptamer-modified magnetic nanoprobe for molecular MR imaging of VEGFR2 on angiogenic vasculature

Authors
 Bongjune Kim ; Jaemoon Yang ; Seungjoo Haam ; Yong-Min Huh ; Jin-Suck Suh ; Sung-Ho Ryu ; Jung Hwan Lee ; Eunji Jang ; Hyun-Ouk Kim ; Jihye Choi ; Myeonghwan Hwang 
Citation
 Nanoscale Research Letters, Vol.8(1) : 399, 2013 
Journal Title
 Nanoscale Research Letters 
ISSN
 1931-7573 
Issue Date
2013
Abstract
Nucleic acid-based aptamers have been developed for the specific delivery of diagnostic nanoprobes. Here, we introduce a new class of smart imaging nanoprobe, which is based on hybridization of a magnetic nanocrystal with a specific aptamer for specific detection of the angiogenic vasculature of glioblastoma via magnetic resonance (MR) imaging. The magnetic nanocrystal imaging core was synthesized using the thermal decomposition method and enveloped by carboxyl polysorbate 80 for water solubilization and conjugation of the targeting moiety. Subsequently, the surface of the carboxylated magnetic nanocrystal was modified with amine-functionalized aptamers that specifically bind to the vascular growth factor receptor 2 (VEGFR2) that is overexpressed on angiogenic vessels. To assess the targeted imaging potential of the aptamer-conjugated magnetic nanocrystal for VEGFR2 markers, the magnetic properties and MR imaging sensitivity were investigated using the orthotopic glioblastoma mouse model. In in vivo tests, the aptamer-conjugated magnetic nanocrystal effectively targeted VEGFR2 and demonstrated excellent MR imaging sensitivity with no cytotoxicity.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/88091
DOI
10.1186/1556-276X-8-399
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Radiology
1. 연구논문 > 5. Research Institutes > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease
Yonsei Authors
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