Cited 11 times in

Comparison of Prognostic Genomic Predictors in Colorectal Cancer

Title
Comparison of Prognostic Genomic Predictors in Colorectal Cancer
Authors
Yun-Yong Park;Sung Sook Lee;Ju-Seog Lee;Scott Kopetz;Sung Soo Kim;Woojin Jeong;Eun Sung Park;Sang Cheul Oh;In-Sun Chu;Bo Hwa Sohn;Sang Bae Kim;Sang Cheol Kim;Jae Yun Lim
Issue Date
2013
Journal Title
PLoS One
ISSN
1932-6203
Citation
PLoS One, Vol.8(4) : e60778, 2013
Abstract
BACKGROUND: Although several prognostic genomic predictors have been identified from independent studies, it remains unclear whether these predictors are actually concordant with respect to their predictions for individual patients and which predictor performs best. We compared five prognostic genomic predictors, the V7RHS, the ColoGuideEx, the Meta163, the OncoDX, and the MDA114, in terms of predicting disease-free survival in two independent cohorts of patients with colorectal cancer. STUDY DESIGN: Using original classification algorithms, we tested the predictions of five genomic predictors for disease-free survival in two cohorts of patients with colorectal cancer (n = 229 and n = 168) and evaluated concordance of predictors in predicting outcomes for individual patients. RESULTS: We found that only two predictors, OncoDX and MDA114, demonstrated robust performance in identifying patients with poor prognosis in 2 independent cohorts. These two predictors also had modest but significant concordance of predicted outcome (r>0.3, P<0.001 in both cohorts). CONCLUSIONS: Further validation of developed genomic predictors is necessary. Despite the limited number of genes shared by OncoDX and MDA114, individual-patient outcomes predicted by these two predictors were significantly concordant.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/87918
DOI
10.1371/journal.pone.0060778
Appears in Collections:
1. 연구논문 > 5. Research Institutes > Institute for Medical Convergence
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
사서에게 알리기
  feedback
Files in This Item:
T201303263.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse