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Tumor Lesion Diameter on Diffusion Weighted Magnetic Resonance Imaging Could Help Predict Insignificant Prostate Cancer in Patients Eligible for Active Surveillance: Preliminary Analysis

Title
 Tumor Lesion Diameter on Diffusion Weighted Magnetic Resonance Imaging Could Help Predict Insignificant Prostate Cancer in Patients Eligible for Active Surveillance: Preliminary Analysis 
Authors
 Dong Hoon Lee ; Kyo Chul Koo ; Byung Ha Chung ; Sung Joon Hong ; Young Deuk Choi ; Koon Ho Rha ; Seung Hwan Lee 
Issue Date
2013
Journal Title
 Journal of Urology 
ISSN
 0022-5347 
Citation
 Journal of Urology, Vol.190(4) : 1213~1217, 2013 
Abstract
PURPOSE: We analyzed the pathological outcomes of candidates for active surveillance according to tumor lesion diameter on diffusion weighted magnetic resonance imaging. MATERIALS AND METHODS: We retrospectively analyzed 188 candidates for active surveillance who had undergone diffusion weighted magnetic resonance imaging before radical prostatectomy between 2006 and 2012. We measured the diameter of the suspicious tumor lesion on diffusion weighted magnetic resonance imaging and stratified the cohort into 2 groups. Group 1 included patients with normal magnetic resonance imaging or a suspicious tumor lesion smaller than 1 cm and group 2 included patients with a suspicious tumor lesion larger than 1 cm. We compared pathological outcomes including insignificant prostate cancer in each group and analyzed whether different tumor diameters resulted in a change in insignificant prostate cancer rates. RESULTS: Group 1 consisted of 115 (61.2%) patients and group 2 included 73 (38.8%) patients. In group 1 magnetic resonance imaging was normal in 72 patients. Mean ± SD diameter of suspicious tumor lesions was 12.0 ± 5.58 mm. Tumor volume was significantly different between the groups (0.73 ± 0.86 vs 1.09 ± 1.07 cm(3), p = 0.018), as was the rate of insignificant prostate cancer (48.7% vs 24.7%, p = 0.001). The rate of insignificant prostate cancer decreased as tumor diameter increased over 1 cm. On multivariate logistic regression analysis the diameter of suspicious tumor lesions was an important predictor of insignificant prostate cancer (OR 0.319, p = 0.014). CONCLUSIONS: Our analysis demonstrates that the simple measurement of the diameter of suspicious tumor lesions on diffusion weighted magnetic resonance imaging could improve the prediction of insignificant prostate cancer in candidates for active surveillance.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/87916
DOI
10.1016/j.juro.2013.03.127
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Urology
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0022534713043875
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