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Impaired mobilization of bone marrow derived CD34 positive mononuclear cells is related to the recurrence of atrial fibrillation after radiofrequency catheter ablation

Title
Impaired mobilization of bone marrow derived CD34 positive mononuclear cells is related to the recurrence of atrial fibrillation after radiofrequency catheter ablation
Authors
Jaemin Shim;Jae Hyung Park;Hui-Nam Pak;Young-Hoon Kim;Moon-Hyoung Lee;Boyoung Joung;Sook Kyoung Kim;Jong Youn Kim
Issue Date
2013
Journal Title
International Journal of Cardiology
ISSN
0167-5273
Citation
International Journal of Cardiology, Vol.162(3) : 179~183, 2013
Abstract
BACKGROUND: We have reported previously that non-ischemic titrated cardiac injury by radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) mobilizes bone marrow derived CD34+ mononuclear cells. We hypothesized that the degree of post-RFCA CD34+ cell mobilization affects the clinical outcome of AF ablation. METHODS AND RESULTS: Fifty-six patients (39 males, 53 ± 13 years) who underwent electrophysiology study (EPS; n=10) or RFCA of AF (n=46) were included. The peripheral blood CD34+ cell count and multiple serologic markers were evaluated before, immediately after the procedure. Results: 1. The percent increase of CD34+ cells (%ΔCD34+) was significant after RFCA as compared to EPS (p < 0.01). 2. The post-RFCA CD34+ cell count was significantly higher in patients who underwent RF energy delivery ≥80 min than those <80 min (p = 0.024). 3. The %ΔCD34+ was linearly correlated with the plasma level of troponin I (R = 0.38, p < 0.01), but not with the non-ablation procedure time (p = NS). 3. During 30.2 ± 2.7 months follow-up, AF recurred in 37% of patients including early recurrence (34.8%). In contrast, the patients in whom AF recurred received a longer duration of RF energy delivery than those remaining in sinus rhythm (p = 0.04), they were associated with lower %ΔCD34+ (p = 0.02). CONCLUSION: CD34+ mononuclear cells were mobilized after catheter ablation by RF energy dose dependent manner, and the duration of RF energy delivery was longer in patients with AF recurrence. However, CD34+ mononuclear cell mobilization was significantly impaired in patients with recurring AF after RFCA.
URI
http://www.sciencedirect.com/science/article/pii/S0167527311004773

http://ir.ymlib.yonsei.ac.kr/handle/22282913/87878
DOI
10.1016/j.ijcard.2011.05.064
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
1. 연구논문 > 1. College of Medicine > Yonsei Biomedical Research Center
Yonsei Authors
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