Cited 0 times in

Severe vitamin D deficiency is associated with non-tuberculous mycobacterial lung disease: A case-control study

Title
 Severe vitamin D deficiency is associated with non-tuberculous mycobacterial lung disease: A case-control study
Authors
 Kyeongman Jeon; Su-Young Kim; Won-Jung Koh; Sung Jae Shin; Boksoon Chang; Byeong-Ho Jeong
Issue Date
2013
Journal Title
 Respirology
ISSN
 1323-7799
Citation
 Respirology, Vol.18(6) : 983~988, 2013
Abstract
BACKGROUND AND OBJECTIVE: Previous studies have found evidence of an association between tuberculosis and vitamin D deficiency (VDD). However, the association between VDD and infection caused by non-tuberculous mycobacteria (NTM) has never been studied. This study evaluated the prevalence and severity of VDD in NTM lung disease and attempted to identify predictive factors. METHODS: Age- and sex-matched case-control study was conducted to assess the prevalence and severity of VDD in patients with NTM lung disease. RESULTS: After adjusting for potential confounding factors, the adjusted mean serum level of 25-hydroxyvitamin D (25(OH)D) levels was lower in 104 patients with NTM lung disease (10.7 ng/mL, 95% confidence interval (CI) 4.5-16.8 ng/mL) than that of 312 controls (13.7 ng/mL, 95% CI 7.4-19.5 ng/mL) (P = 0.012). Although the prevalence of VDD defined as serum 25(OH)D level <20 ng/mL was not different, severe VDD defined as serum 25(OH)D level <10 ng/mL was more prevalent in patients (P < 0.001). In multivariate analysis, severe (but not mild) VDD was independently associated with NTM lung disease (adjusted odds ratio 3.9, 95% CI 1.9-8.5, P < 0.001). CONCLUSIONS: Patients with NTM lung disease have a high prevalence of severe VDD and VDD was independently associated with NTM lung disease. Further studies are needed to examine causality.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/87866
DOI
10.1111/resp.12109
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Microbiology
Yonsei Authors
사서에게 알리기
  feedback
Files in This Item:
T201303191.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse