Cited 0 times in

Mycobacterial Genotypes Are Associated With Clinical Manifestation and Progression of Lung Disease Caused by Mycobacterium abscessus and Mycobacterium massiliense

Title
 Mycobacterial Genotypes Are Associated With Clinical Manifestation and Progression of Lung Disease Caused by Mycobacterium abscessus and Mycobacterium massiliense
Authors
 Sung Jae Shin; Go-Eun Choi; Won-Jung Koh; Kyeongman Jeon; Byeong-Ho Jeong; Sook Young Woo; Sang-Nae Cho
Issue Date
2013
Journal Title
 Clinical Infectious Diseases
ISSN
 1058-4838
Citation
 Clinical Infectious Diseases, Vol.57(1) : 32~39, 2013
Abstract
BACKGROUND: Mycobacterium abscessus and Mycobacterium massiliense, which cause lung disease, are variable in their clinical manifestation and progression. We hypothesized that mycobacterial genotypes represent their pathogenic phenotypes, which would result in particular genotypes being associated with disease progression. METHODS: Variable number tandem repeat (VNTR) loci were selected to establish a genotype assay that was capable of differentiating patients with heterogeneous prognoses in the development cohort (48 isolates). The analysis was reevaluated in the validation cohort (63 isolates). RESULTS: A total of 53 M. abscessus and 58 M. massiliense isolates were assembled into 3 clusters based on their VNTR genotyping. The patients in cluster A were more likely to have stable disease of the nodular bronchiectatic form; 100% of M. abscessus patients and 96% of M. massiliense patients were followed without antibiotic treatment for >24 months after diagnosis. In contrast, the patients in cluster B were more likely to have progressive disease of the nodular bronchiectatic form; 96% of M. abscessus patients and 81% of M. massiliense patients started antibiotic treatment within 24 months after diagnosis. All patients in cluster C had fibrocavitary disease and started antibiotic treatment immediately after diagnosis. The genetic distance of each clinical isolate from the reference strain was associated with the highest likelihood of disease progression and a disease phenotype of the fibrocavitary form (P < .001). CONCLUSIONS: Mycobacterial genotyping of M. abscessus and M. massiliense may provide valuable information for predicting disease phenotype and progression.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/87842
DOI
10.1093/cid/cit172
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Microbiology
Yonsei Authors
사서에게 알리기
  feedback
Link
 http://cid.oxfordjournals.org/content/57/1/32.long
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse