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Increasing prevalence of bla(OXA-23)-carrying Acinetobacter baumannii and the emergence of bla(OXA-182)-carrying Acinetobacter nosocomialis in Korea

Title
Increasing prevalence of bla(OXA-23)-carrying Acinetobacter baumannii and the emergence of bla(OXA-182)-carrying Acinetobacter nosocomialis in Korea
Authors
Yangsoon Lee;Young-Ree Kim;Yunsop Chong;Kyungwon Lee;Seok Hoon Jeong;Dongeun Yong;Ji Hyun Cho;Seong Hee Lee;Kyutaeg Lee;Young Uh;Jong-Hee Shin;Wonkeun Song;Yeon-Joon Park;Jayoung Kim
Issue Date
2013
Journal Title
Diagnostic Microbiology and Infectious Disease
ISSN
0732-8893
Citation
Diagnostic Microbiology and Infectious Disease, Vol.77(2) : 160~163, 2013
Abstract
Carbapenem-resistant Acinetobacter spp. have been increasingly reported worldwide with the production of OXA-type carbapenemases as the main mechanism of carbapenem resistance. The prevalent bla(OXA) genes are known to vary significantly depending on time and place of isolation. We investigated the prevalence of bla(OXA) genes by PCR in Acinetobacter spp. isolated in Korea. Among a total of 336 isolates collected from Hospital A from 2002 to 2011, the overall proportion of bla(OXA)-23-like, ISAba1-associated bla(OXA-51)-like, and bla(OXA-182) genes were 44.0%, 49.7%, and 5.1%, respectively. The bla(OXA-58)-like gene was detected in only 1 isolate. A drastic increase in Acinetobacter isolates with bla(OXA-23)-like genes and a decrease in isolates harboring ISAba1-associated bla(OXA-51)-like genes have been observed since the mid-2000s. The bla(OXA-23)-like genes were detected in all carbapenem-nonsusceptible isolates collected in 2011 from 9 hospitals. The OXA-182, which belongs to the fifth group of OXA-type carbapenemase, was detected in Acinetobacter baumannii isolates recovered as early as 2002. It is worrisome results that bla(OXA-182)-carrying Acinetobacter nosocomialis has emerged and caused outbreaks of infection.
URI
http://www.sciencedirect.com/science/article/pii/S0732889313003416

http://ir.ymlib.yonsei.ac.kr/handle/22282913/87731
DOI
10.1016/j.diagmicrobio.2013.06.009
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Laboratory Medicine
Yonsei Authors
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