Cited 47 times in
Survival outcome of patients with spontaneously ruptured hepatocellular carcinoma treated surgically or by transarterial embolization
DC Field | Value | Language |
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dc.contributor.author | 이정일 | - |
dc.date.accessioned | 2014-12-18T09:05:08Z | - |
dc.date.available | 2014-12-18T09:05:08Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87505 | - |
dc.description.abstract | AIM: To evaluate clinical outcomes of patients that underwent surgery, transarterial embolization (TAE), or supportive care for spontaneously ruptured hepatocellular carcinoma (HCC). METHODS: A consecutive 54 patients who diagnosed as spontaneously ruptured HCC at our institution between 2003 and 2012 were retrospectively enrolled. HCC was diagnosed based on the diagnostic guidelines issued by the 2005 American Association for the Study of Liver Diseases. HCC rupture was defined as disruption of the peritumoral liver capsule with enhanced fluid collection in the perihepatic area adjacent to the HCC by dynamic liver computed tomography, and when abdominal paracentesis showed an ascitic red blood cell count of > 50000 mm(3)/mL in bloody fluid. RESULTS: Of the 54 patients, 6 (11.1%) underwent surgery, 25 (46.3%) TAE, and 23 (42.6%) supportive care. The 2-, 4- and 6-mo cumulative survival rates at 2, 4 and 6 mo were significantly higher in the surgery (60%, 60% and 60%) or TAE (36%, 20% and 20%) groups than in the supportive care group (8.7%, 0% and 0%), respectively (each, P < 0.01), and tended to be higher in the surgical group than in the TAE group. Multivariate analysis showed that serum bilirubin (HR = 1.09, P < 0.01), creatinine (HR = 1.46, P = 0.04), and vasopressor requirement (HR = 2.37, P = 0.02) were significantly associated with post-treatment mortality, whereas surgery (HR = 0.41, P < 0.01), and TAE (HR = 0.13, P = 0.01) were inversely associated with post-treatment mortality. CONCLUSION: Post-treatment survival after surgery or TAE was found to be better than after supportive care, and surgery tended to provide better survival benefit than TAE. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Carcinoma, Hepatocellular/mortality | - |
dc.subject.MESH | Carcinoma, Hepatocellular/pathology | - |
dc.subject.MESH | Carcinoma, Hepatocellular/surgery | - |
dc.subject.MESH | Carcinoma, Hepatocellular/therapy* | - |
dc.subject.MESH | Chi-Square Distribution | - |
dc.subject.MESH | Embolization, Therapeutic*/adverse effects | - |
dc.subject.MESH | Embolization, Therapeutic*/mortality | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hepatectomy*/adverse effects | - |
dc.subject.MESH | Hepatectomy*/mortality | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Liver Neoplasms/mortality | - |
dc.subject.MESH | Liver Neoplasms/pathology | - |
dc.subject.MESH | Liver Neoplasms/surgery | - |
dc.subject.MESH | Liver Neoplasms/therapy* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Rupture, Spontaneous | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Survival outcome of patients with spontaneously ruptured hepatocellular carcinoma treated surgically or by transarterial embolization | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Young-Joo Jin | - |
dc.contributor.googleauthor | Jin-Woo Lee | - |
dc.contributor.googleauthor | Seoung-Wook Park | - |
dc.contributor.googleauthor | Jung Il Lee | - |
dc.contributor.googleauthor | Don Haeng Lee | - |
dc.contributor.googleauthor | Young Soo Kim | - |
dc.contributor.googleauthor | Soon Gu Cho | - |
dc.contributor.googleauthor | Yong Sun Jeon | - |
dc.contributor.googleauthor | Kun Young Lee | - |
dc.contributor.googleauthor | Seung-Ik Ahn | - |
dc.identifier.doi | 10.3748/wjg.v19.i28.4537 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03122 | - |
dc.relation.journalcode | J02795 | - |
dc.identifier.eissn | 2219-2840 | - |
dc.identifier.pmid | 23901230 | - |
dc.subject.keyword | Ruptured hepatocellular carcinoma | - |
dc.subject.keyword | Surgery | - |
dc.subject.keyword | Transarterial embolization | - |
dc.contributor.alternativeName | Lee, Jung Il | - |
dc.contributor.affiliatedAuthor | Lee, Jung Il | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 19 | - |
dc.citation.number | 28 | - |
dc.citation.startPage | 4537 | - |
dc.citation.endPage | 4544 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF GASTROENTEROLOGY, Vol.19(28) : 4537-4544, 2013 | - |
dc.identifier.rimsid | 34268 | - |
dc.type.rims | ART | - |
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