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법의 분야에서 DNA 메틸화를 이용한 연령 추정

Other Titles
 DNA Methylation-Based Age Estimation in the Forensic Field 
Authors
 신경진 ; 안자현 ; 양우익 ; 이환영 ; 최아진 
Citation
 Korean Journal of Legal Medicine (대한법의학회지), Vol.37(1) : 1~8, 2013 
Journal Title
 Korean Journal of Legal Medicine (대한법의학회지) 
ISSN
 1225-0589 
Issue Date
2013
Abstract
The estimation of age is an important issue in forensic science, and the forensic community has attempted many times to establish methods for solving this issue. Aging leads to alterations in tissues and organs at the molecular level. These alterations at the molecular level may aid forensic scientists to estimate the age of a living person or a dead body. Initially, the focus was on the genetic components of aging, but recently, epigenetic mechanisms have emerged as the key contributors to the alterations in genome structure and function that accompany aging. In particular, DNA methylation is one of the best-understood mechanisms, and it has been suggested as a promising biomarker for age estimation in many studies. In this review, we summarize the recent studies on age-associated DNA methylation changes in different tissues and discuss its possible and practical applications in forensics.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/87485
DOI
10.7580/kjlm.2013.37.1.1
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
1. 연구논문 > 1. College of Medicine > Dept. of Forensic Medicine
Yonsei Authors
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