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Preoperative Prediction of Ductal Carcinoma in situ Underestimation of the Breast using Dynamic Contrast Enhanced and Diffusion-weighted Imaging

Other Titles
 역동적 유방 자기공명 영상 및 확산 강조영상을 이용한 관상피내암종 저평가 수술전 예측 
Authors
 Mina Park  ;  Eun-Kyung Kim  ;  Min Jung Kim  ;  Hee Jung Moon 
Citation
 Journal of the Korean Society of Magnetic Resonance in Medicine, Vol.17(2) : 101-109, 2013 
Journal Title
Journal of the Korean Society of Magnetic Resonance in Medicine(대한자기공명의과학회지)
ISSN
 1226-9751 
Issue Date
2013
Keywords
Breast malignancy ; Underestimation ; Breast core needle biopsy ; Dynamic contrast enhanced magnetic resonance imaging ; Diffusion-weighted magnetic resonance imaging
Abstract
Objective
To investigate roles of dynamic contrast enhanced magnetic resonance (DCE MR) and diffusion-weighted (DW) imaging in preoperative prediction of underestimation of ductal carcinoma in situ (DCIS)≥2cm on US guided core needle biopsy.

Materials and Methods
Twenty two patients with DCIS on US-guided 14 gauge core needle biopsy were included. Patients were divided into a group with and without DCIS underestimation based on histopathology. MR images including DCE and DW imaging were obtained with a 3.0-T MR. The lesion type (mass or non-mass), enhancement pattern, peak enhancement, and apparent diffusion coefficient (ADC) values of proven malignant masses were generated using software of CADstream and compared between two groups using Fisher's exact test and Mann Whitney test.

Results
Eight patients were in the group with underestimation and 14 patients were in the group without underestimation. The lesion type and enhancement pattern were not different between two groups (P values = 1.000 and 0.613, respectively). The median peak enhancement of lesions with underestimation was 159.5%, higher than 133.5% of those without underestimation, but not significant (P value = 0.413). The median ADC value of lesions with underestimation was 1.26×10-3 mm2/sec, substantially lower than 1.35×10-3 mm2/sec of those without underestimation (P value = 0.094).

Conclusion
ADC values had the potential to preoperatively predict DCIS underestimation on US-guided core needle biopsy, although a large prospective series study should be conducted to confirm these results.
Files in This Item:
T201302543.pdf Download
DOI
10.13104/jksmrm.2013.17.2.101
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min Jung(김민정) ORCID logo https://orcid.org/0000-0003-4949-1237
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Park, Mina(박미나) ORCID logo https://orcid.org/0000-0002-2005-7560
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87437
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