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Amphetamine dephosphorylates ERM proteins in the nucleus accumbens core and lithium attenuates its effects

Title
Amphetamine dephosphorylates ERM proteins in the nucleus accumbens core and lithium attenuates its effects
Authors
Wha Young Kim;Ju Kyong Jang;Jeong-Hoon Kim;Joong-Keun Shin
Issue Date
2013
Journal Title
Neuroscience Letters
ISSN
0304-3940
Citation
Neuroscience Letters, Vol.552(null) : 103~107, 2013
Abstract
The ezrin–radixin–moesin (ERM) proteins have been implicated not only in cell-shape determination but also in cellular signaling pathway. We have previously shown that cocaine decreases phosphorylation levels of these proteins in the nucleus accumbens (NAcc), an important brain area mediating addictive behaviors. Here we further revealed that the phosphorylation levels of ERM were decreased in the NAcc core, but not in the shell, by a single injection of amphetamine (AMPH) (2 mg/kg, IP). When lithium (100 mg/kg, IP) was co-administered with AMPH, the decreases of phosphorylation levels for ERM by AMPH were recovered back to basal levels in the NAcc core. Together, these results suggest that psychomotor stimulants like AMPH regulate phosphorylation levels of ERM in the NAcc core and lithium-involved signaling pathway has a regulatory role in the opposite direction in this site.
URI
http://www.sciencedirect.com/science/article/pii/S0304394013006836

http://ir.ymlib.yonsei.ac.kr/handle/22282913/87408
DOI
10.1016/j.neulet.2013.07.037
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Physiology
Yonsei Authors
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