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Risk prediction for malignant conversion of oral epithelial dysplasia by hypoxia related protein expression

Title
Risk prediction for malignant conversion of oral epithelial dysplasia by hypoxia related protein expression
Authors
XIANGLAN ZHANG;SEONHUI HAN;JIN KIM;IN-HO CHA;EUN-JOO CHOI;KI-YEOL KIM;MI HEON RYU;HYE-YEON HAN
Issue Date
2013
Journal Title
Pathology
ISSN
0031-3025
Citation
Pathology, Vol.45(5) : 478~483, 2013
Abstract
AIMS: Increased aerobic glycolysis is a unique finding in cancers and hypoxia-related proteins are associated with aerobic glycolysis. Therefore, we aimed to investigate whether hypoxia-related proteins can be predictive markers for malignant conversion of oral premalignant lesions with epithelial dysplasia (OED). METHODS: Expression of HIF-1α, Glut-1 and CA9 were detected in clinical samples of eight normal oral mucosa, 85 transitional areas of oral squamous cell carcinoma (OSCC) and 28 OED with or without malignant conversion using immunohistochemistry and were also comparatively detected in immortalised human oral keratinocyte (IHOK) and OSCC cell lines under hypoxia using immunoblotting. RESULTS: Sequential expression of HIF-1α, Glut-1 and CA9 was found both in transitional areas of OSCC and cell lines of IHOK and OSCC under hypoxia, supporting hypoxia-aerobic glycolysis-acidosis axis. Expression of all proteins showed significant association with malignant conversion of OED and CA9 was an independent risk factor of malignant transformation of OED. But the predictability of malignant transformation was improved when all three proteins were applied together. CONCLUSION: High expression of CA9 was an independent predictive marker of malignant conversion. Moreover, the combined application of these three proteins may be useful to assess the risk of malignant conversion of OED.
URI
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=01268031-201308000-00005&LSLINK=80&D=ovft

http://ir.ymlib.yonsei.ac.kr/handle/22282913/87405
DOI
10.1097/PAT.0b013e3283632624
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Oral and Maxillofacial Surgery
1. 연구논문 > 2. College of Dentistry > Dept. of Oral Pathology
1. 연구논문 > 5. Research Institutes > Oral Cancer Research Institute
Yonsei Authors
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