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The effect of alfentanil versus ketamine on the intubation condition and hemodynamics with low-dose rocuronium in children

Authors
 Ji Young Kim ; Jong Seok Lee ; Hyun Jeong Kwak ; Youngjun Kwon ; Yong Beom Kim ; Hee Yeon Park 
Citation
 Journal of Anesthesia, Vol.27(1) : 7~11, 2013 
Journal Title
 Journal of Anesthesia 
ISSN
 0913-8668 
Issue Date
2013
Abstract
PURPOSE: We investigated the effect of alfentanil and ketamine on the intubation condition and hemodynamic parameters during propofol anesthesia with low-dose rocuronium in children. METHODS: Fifty-four children, aged 3-9 years undergoing tonsillectomy, were randomly allocated to receive either alfentanil 20 μg/kg (alfentanil group, n = 27) or ketamine 0.5 mg/kg (ketamine group, n = 27) 1 min before anesthesia induction. Anesthesia was induced with propofol 2.5 mg/kg and rocuronium 0.3 mg/kg and maintained with propofol infusion (6 mg/kg/h). The neuromuscular relaxation was monitored, and intubation conditions, hemodynamic changes, and recovery time were assessed. RESULTS: All patients were successfully intubated and there were no significant differences in the intubation conditions between alfentanil and ketamine groups. At the time of tracheal intubation, the median [inter-quartile range] twitch height was similar between two groups (37 [4-48] % in the alfentanil group vs. 29 [4-43.5] % in the ketamine group, p = 0.326). CONCLUSIONS: This study showed that both ketamine 0.5 mg/kg and alfentanil 20 μg/kg provided adequate intubation condition during propofol induction with low-dose rocuronium in children. The mean arterial pressure and heart rate were higher in the ketamine group after propofol injection but they remained within the normal limit in both groups throughout the study period.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/87320
DOI
10.1007/s00540-012-1485-4
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Anesthesiology and Pain Medicine
Yonsei Authors
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Link
 http://link.springer.com/article/10.1007%2Fs00540-012-1485-4
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