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Histopathologic Validation of Optical Coherence Tomography Findings of Non-Apposed Side-Branch Struts in Porcine Arteries

Authors
 Ae-Young Her  ;  Jung-Sun Kim  ;  Yong Hoon Kim  ;  Dong-Ho Shin  ;  Byoung-Keuk Kim  ;  Young-Guk Ko  ;  Donghoon Choi  ;  Yangsoo Jang  ;  Myeong-Ki Hong 
Citation
 JOURNAL OF INVASIVE CARDIOLOGY, Vol.25(7) : 364-366, 2013 
Journal Title
JOURNAL OF INVASIVE CARDIOLOGY
ISSN
 1042-3931 
Issue Date
2013
MeSH
Animals ; Coronary Vessels/pathology* ; Drug-Eluting Stents*/adverse effects ; Incidence ; Metals* ; Models, Animal ; Muscle, Smooth, Vascular/pathology ; Neointima/epidemiology ; Neointima/pathology ; Risk Factors ; Sirolimus/analogs & derivatives ; Stents*/adverse effects ; Sus scrofa ; Tomography, Optical Coherence*
Keywords
cardiac imaging ; restenosis ; stenting
Abstract
Abstract: Background. The presence of uncovered struts overlying side branch is considered to be a potential risk of stent thrombosis. The accuracy in detection of neointimal strut coverage at branch point by optical coherence tomography (OCT) has not been validated in comparison with histology. Methods. A total of 5 stents (3 drug-eluting stents and 2 bare-metal stents) were implanted in the bifurcation segment of normal coronary arteries in 4 domestic swine (weight, 25-40 kg). The animals underwent follow-up OCT at 30 days after stent implantation and were then sacrificed for histologic evaluation. The neointimal coverage of the non-apposed struts over the side branch was assessed by light microscopy. Every millimeter of the stent was specified by the OCT frame rate, and comparisons between OCT and pathologic findings were performed through precise histological-OCT frame matching. Results. OCT images at the side branch corresponded well with histological cross-sections. The tissues covering struts as assessed by OCT contained smooth muscle cells with proteoglycan-collagen matrix, but platelets are attached above the neointima in one of them on histologic examination, suggesting that most of the struts were well healed, with normal neointimal coverage. Conclusion. This study demonstrated the accuracy of OCT for the detection of neointimal coverage of non-apposed struts over the side branch.
Full Text
http://www.invasivecardiology.com/articles/histopathologic-validation-optical-coherence-tomography-findings-non-apposed-side-branch-st
DOI
23813068
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Byeong Keuk(김병극) ORCID logo https://orcid.org/0000-0003-2493-066X
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Shin, Dong Ho(신동호) ORCID logo https://orcid.org/0000-0002-7874-5542
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Hong, Myeong Ki(홍명기) ORCID logo https://orcid.org/0000-0002-2090-2031
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87305
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